Selective breeding for endurance running capacity affects cognitive but not motor learning in rats.
Selective breeding for endurance running capacity affects cognitive but not motor learning in rats.
复制标题
DOI：
10.1016/j.physbeh.2012.01.011
复制
发表时间：
2012-05-15
影响因子：
2.9
通讯作者：
Kainulainen, Heikki
中科院分区：
文献类型：
--
作者：
Wikgren, Jan;Mertikas, Georgios G.;Raussi, Pekka;Tirkkonen, Riina;Ayravainen, Laura;Pelto-Huikko, Markku;Koch, Lauren G.;Britton, Steven L.;Kainulainen, Heikki
利用氧气的能力已被证明会影响多种通常被认为对生存有益的生理因素。由于学习能力被视为哺乳动物生存的核心因素之一，因此我们研究了耐力跑（有氧能力的指标）的选择性育种是否也会对学习产生影响。老鼠选择性地繁殖超过 23 代，以使其具有执行强制跑步机跑步的能力，并接受食欲驱动的歧视逆转经典条件反射任务、交替 T 迷宫任务和规则改变（从换档获胜规则改为保持获胜规则）和运动学习任务的训练。在辨别逆转和 T 迷宫任务中，高能力跑步者 (HCR) 大鼠的表现优于低能力跑步者 (LCR) 大鼠，尤其是在需要灵活认知的阶段。在 Rotarod（运动学习）任务中，HCR 动物总体上更加敏捷，但作为训练函数，学习速度与 LCR 组相似。我们的结论是，利用氧气的内在能力尤其与需要涉及灵活认知的大脑结构可塑性的任务相关。
The ability to utilize oxygen has been shown to affect a wide variety of physiological factors often considered beneficial for survival. As the ability to learn can be seen as one of the core factors of survival in mammals, we studied whether selective breeding for endurance running, an indication of aerobic capacity, also has an effect on learning. Rats selectively bred over 23 generations for their ability to perform forced treadmill running were trained in an appetitively motivated discrimination-reversal classical conditioning task, an alternating T-maze task followed by a rule change (from a shift-win to stay-win rule) and motor learning task. In the discrimination-reversal and T-maze tasks, the high-capacity runner (HCR) rats outperformed the low-capacity runner (LCR) rats, most notably in the phases requiring flexible cognition. In the Rotarod (motor-learning) task, the HCR animals were overall more agile but learned at a similar rate with the LCR group as a function of training. We conclude that the intrinsic ability to utilize oxygen is associated especially with tasks requiring plasticity of the brain structures implicated in flexible cognition.
登录
查看更多内容
影响因子：
7.1
作者：
GOLD, PE
通讯作者：
GOLD, PE
影响因子：
5.8
作者：
Lustig, Cindy;Shah, Priti;Seidler, Rachael;Reuter-Lorenz, Patricia A.
通讯作者：
Reuter-Lorenz, Patricia A.
影响因子：
3.3
作者：
Howlett, Richard A.;Kirkton, Scott D.;Wagner, Peter D.
通讯作者：
Wagner, Peter D.
影响因子：
64.8
作者：
Kempermann, G;Kuhn, HG;Gage, FH
通讯作者：
Gage, FH
影响因子：
2.7
作者：
Green, John T.;Chess, Amy C.;Thanellou, Alexandra
通讯作者：
Thanellou, Alexandra