Increases in endogenous progesterone attenuate smoking in a cohort of nontreatment seeking women: An exploratory prospective study.
Increases in endogenous progesterone attenuate smoking in a cohort of nontreatment seeking women: An exploratory prospective study.
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内源性孕酮的增加减少了非寻求治疗的女性的吸烟：一项探索性前瞻性研究。
DOI：
10.1111/adb.12918
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发表时间：
2021-03
影响因子：
3.4
通讯作者：
Saladin ME
中科院分区：
文献类型：
--
作者：
Baker NL;Gray KM;Ramakrishnan V;Tomko RL;McClure EA;Carpenter MJ;Saladin ME
尽管在预防和治疗方面取得了进展，但吸烟仍然是美国可预防死亡的主要原因。虽然男性和女性同样有可能尝试戒烟，但女性在戒烟治疗期间和之后实现戒烟的可能性要小得多。最近的证据表明，卵巢激素水平可能在女性吸烟者成功戒烟的尝试中发挥作用。这项探索性前瞻性观察性研究的主要目的是评估成年女性吸烟者（n=115）中孕酮和雌二醇的参与者水平与每天吸烟相关香烟之间的相关性。主要研究结果是使用每日吸烟日记收集的两周观察期间自我报告的每日吸烟量（CPD）。此外，参与者每天收集唾液，从中获得激素水平（孕酮和雌二醇）。较高的参与者内孕酮水平与CPD显著降低相关（p=.008），而参与者内雌二醇水平与CPD无关（p=.25）。回归模型表明，一个单一的变化，吸烟行为的轨迹内参与者孕酮和雌二醇。当孕酮值低于变化点时，参与者内孕酮水平与吸烟行为之间存在显著的负相关关系（p= 0.025），而参与者内孕酮水平较高时，这种关系减弱（p= 0.59）。当雌二醇低于（p= 0.92）或高于（p= 0.16）变化点时，雌二醇对吸烟行为的影响不显著。参与者体内孕酮水平较高，而不是雌二醇水平较高，与非寻求治疗的女性吸烟者的CPD降低有关。
Despite advances in prevention and treatment, cigarette smoking remains a leading cause of preventable death in the United States. While men and women are equally likely to attempt to quit smoking cigarettes, women are far less likely to achieve abstinence both during and following cessation treatment. Recent evidence suggests that ovarian hormone levels may play a role in successful abstinence attempts in women smokers. The primary goal of this exploratory prospective observational study was to estimate the association between within participant levels of progesterone and estradiol with associated cigarettes smoked per day in adult women smokers (n=115). The primary study outcome was self-reported cigarettes smoked per day (CPD) during a two-week observational period collected using a daily smoking diary. Additionally, participants collected saliva daily, from which hormone levels (progesterone and estradiol) were derived. Higher within-participant progesterone levels were associated with a significant decrease in CPD (p=.008) whereas within-participant estradiol levels were unrelated to CPD (p=.25). Regression models indicated a single change in the trajectory of smoking behavior for both within participant progesterone and estradiol. When progesterone values were below the change point, there was a significant inverse relationship between within-participant progesterone levels and smoking behavior (p=.025) while the relationship was attenuated for higher within-participant progesterone levels (p=.59). The effect of estradiol on smoking behavior was not significant when it was either below (p=.92) or above (p=.16) the change point. Higher within-participant levels of progesterone but not estradiol, are associated with reduced CPD in non-treatment seeking women smokers.
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影响因子：
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通讯作者：
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