Radioanalytical Techniques to Quantitatively Assess the Biological Uptake and In Vivo Behavior of Hazardous Substances.
Radioanalytical Techniques to Quantitatively Assess the Biological Uptake and In Vivo Behavior of Hazardous Substances.
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DOI：
10.3390/molecules25173985
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发表时间：
2020-09-01
期刊：
影响因子：
--
通讯作者：
Jeon J
中科院分区：
文献类型：
--
作者：
Lee JY;Mushtaq S;Park JE;Shin HS;Lee SY;Jeon J
过去几十年来，人们对环境中有害物质暴露的担忧不断增加，因为这些物质对人类健康有不利影响。用于监测有害物质的生物吸收及其体内时空行为的方法必须准确可靠。放射性标记化学和放射分析方法的最新进展促进了有毒物质的定量分析，并且可以使用核成像仪器实现全身成像。在此，我们回顾了有关用于研究有害物质（包括工业化学品、纳米材料和微生物）的生物分布、吸收和积累变化的放射分析方法的最新文献。我们首先概述用于制备体内实验放射性示踪剂的放射性同位素。然后我们总结了涉及放射性标记毒素的分子成像研究及其定量评估的结果。我们对放射分析方法在未来环境研究中的应用进行了总结。
Concern about environmental exposure to hazardous substances has grown over the past several decades, because these substances have adverse effects on human health. Methods used to monitor the biological uptake of hazardous substances and their spatiotemporal behavior in vivo must be accurate and reliable. Recent advances in radiolabeling chemistry and radioanalytical methodologies have facilitated the quantitative analysis of toxic substances, and whole-body imaging can be achieved using nuclear imaging instruments. Herein, we review recent literature on the radioanalytical methods used to study the biological distribution, changes in the uptake and accumulation of hazardous substances, including industrial chemicals, nanomaterials, and microorganisms. We begin with an overview of the radioisotopes used to prepare radiotracers for in vivo experiments. We then summarize the results of molecular imaging studies involving radiolabeled toxins and their quantitative assessment. We conclude the review with perspectives on the use of radioanalytical methods for future environmental research.
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