Localization of estrogen receptors alpha and beta in the articular surface of the rat femur.
Localization of estrogen receptors alpha and beta in the articular surface of the rat femur.
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DOI：
10.1267/ahc.06015
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发表时间：
2007-02-27
影响因子：
2.4
通讯作者：
Kubo T
中科院分区：
文献类型：
--
作者：
Oshima Y;Matsuda K;Yoshida A;Watanabe N;Kawata M;Kubo T
研究表明，关节软骨的退化和骨关节炎（OA）与性别和雌激素有关。尽管许多研究者报道了雌激素受体（ER）α和β在关节软骨中的存在，但这些受体的定位及其在体内表达的差异尚未得到明确证实。我们对ERα和ERβ进行了免疫荧光染色，以阐明ER的定位，并注意性别和衰老过程对这些受体的影响。结果表明，雌激素受体α和β在成年大鼠关节软骨和软骨下骨层均有表达。我们还观察到这些受体在未成年大鼠中的高表达。与此相反，它们的表达水平下降，在卵巢切除模型，作为一个模拟绝经后，并在老年雌性大鼠。因此，本研究提示雌激素和ER表达对关节面代谢的直接影响。
It has been suggested that the degradation of the articular cartilage and osteoarthritis (OA) are associated with gender and the estrogen hormone. Although many investigators have reported the presence of the estrogen receptors (ERs) α and β in the articular cartilage, the localization of these receptors and the difference in their in vivo expression have not yet been clearly demonstrated. We performed immunofluorescence staining of ERα and ERβ to elucidate the localization of the ERs and to note the effects of gender and the aging process on these receptors. The results revealed that ERα and ERβ were expressed in the articular cartilage and subchondral bone layers of adult rats of both sexes. We also observed the high expression of these receptors in immature rats. In contrast, their expression levels decreased in an ovariectomised model, as a simulation of postmenopause, and in aged female rats. Therefore, this study suggests the direct effects of estrogen and ER expression on articular surface metabolism.
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影响因子：
2.5
作者：
Creutz, LM;Kritzer, MF
通讯作者：
Kritzer, MF
DOI：
10.1073/pnas.96.1.208
发表时间：
1999-01-05
影响因子：
11.1
作者：
Shim, WS;DiRenzo, J;Jeng, MH
通讯作者：
Jeng, MH
影响因子：
7
作者：
Ushiyama, T;Ueyama, H;Hukuda, S
通讯作者：
Hukuda, S
影响因子：
3.2
作者：
Oshima, Y;Watanabe, N;Kubo, T
通讯作者：
Kubo, T
DOI：
10.1073/pnas.052707299
发表时间：
2002-03-05
影响因子：
11.1
作者：
Orikasa, C;Kondo, Y;Sakuma, Y
通讯作者：
Sakuma, Y