The vascular S1P gradient-cellular sources and biological significance.
The vascular S1P gradient-cellular sources and biological significance.
复制标题
血管 S1P 梯度细胞来源和生物学意义。
DOI：
10.1016/j.bbalip.2008.07.003
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发表时间：
2008-09
影响因子：
4.8
通讯作者：
Michaud, Jason
中科院分区：
文献类型：
--
作者：
Hla, Timothy;Venkataraman, Krishnan;Michaud, Jason
1-磷酸鞘氨醇（S1 P）是鞘磷脂代谢的产物，在循环系统中富集，而据估计在组织间质液中含量要低得多。这种浓度梯度，称为血管S1 P梯度，似乎是底物可用性和代谢酶作用的结果。血液和淋巴中的S1 P水平估计在μM范围内。在免疫系统中，需要S1 P梯度作为淋巴细胞和造血细胞运输的空间线索。在发生血管通透性增强的炎症反应期间，血管外室中的S1 P受体可获得S1 P的爆发，这可能有助于组织反应。因此，血管S1 P梯度的存在被认为有助于生理和病理条件。从进化的角度来看，S1 P受体可能与闭合血管系统的出现以及造血细胞进出血管系统的运输模式共同进化。
Sphingosine 1-phosphate (S1P), a product of sphingomyelin metabolism, is enriched in the circulatory system whereas it is estimated to be much lower in interstitial fluids of tissues. This concentration gradient, termed the vascular S1P gradient appears to form as a result of substrate availability and the action of metabolic enzymes. S1P levels in blood and lymph are estimated to be in the μM range. In the immune system, the S1P gradient is needed as a spatial cue for lymphocyte and hematopoietic cell trafficking. During inflammatory reactions in which enhanced vascular permeability occurs, a burst of S1P becomes available to its receptors in the extravascular compartment, which likely contributes to the tissue reactions. Thus, the presence of the vascular S1P gradient is thought to contribute to physiological and pathological conditions. From an evolutionary perspective, S1P receptors may have co-evolved with the advent of a closed vascular system and the trafficking paradigms for hematopoietic cells to navigate in and out of the vascular system.
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影响因子：
56.9
作者：
Dobrosotskaya, IY;Seegmiller, AC;Rawson, RB
通讯作者：
Rawson, RB
影响因子：
30.5
作者：
Boehm, Thomas;Bleul, Conrad C.
通讯作者：
Bleul, Conrad C.
影响因子：
15.9
作者：
Chae, SS;Paik, JH;Hla, T
通讯作者：
Hla, T
DOI：
10.1016/j.prostaglandins.2004.01.006
发表时间：
2004-01-01
影响因子：
2.9
作者：
Chae, SS;Proia, RL;Hla, T
通讯作者：
Hla, T
影响因子：
30.5
作者：
Cinamon, Guy;Zachariah, Marcus A.;Cyster, Jason G.
通讯作者：
Cyster, Jason G.