A double-layer hydrogel based on alginate-carboxymethyl cellulose and synthetic polymer as sustained drug delivery system.
A double-layer hydrogel based on alginate-carboxymethyl cellulose and synthetic polymer as sustained drug delivery system.
复制标题
一种基于海藻酸钠 - 羧甲基纤维素和合成聚合物的双层水凝胶作为持续药物递送系统。
DOI：
10.1038/s41598-021-88503-1
复制
发表时间：
2021-04-28
影响因子：
4.6
通讯作者：
Yang X
中科院分区：
文献类型：
--
作者：
Hu Y;Hu S;Zhang S;Dong S;Hu J;Kang L;Yang X
制备了一种基于多糖和合成聚合物的新型双层、pH敏感复合水凝胶缓释系统，该系统具有不同内外水凝胶的组合功能。基于海藻酸钠（SA）和羧甲基纤维素（CMC）的多糖内核通过物理交联形成，具有pH敏感特性。通过化学交联引入稳定性增强的合成聚合物外层，以消除内核的膨胀和内部物质的扩散。对双层水凝胶的物理化学结构进行了表征。药物释放结果表明，通过改变水凝胶层的组成或厚度，可以调节水凝胶对不同模型药物的缓释效果。对牛血清白蛋白（BSA）和吲哚美辛的显著缓释效果表明，这种双层水凝胶可开发成为一种新型的生物活性物质或药物缓释系统，在药物和功能性食品中具有潜在应用。
A new double-layer, pH-sensitive, composite hydrogel sustained-release system based on polysaccharides and synthetic polymers with combined functions of different inner/outer hydrogels was prepared. The polysaccharides inner core based on sodium alginate (SA) and carboxymethyl cellulose (CMC), was formed by physical crosslinking with pH-sensitive property. The synthetic polymer out-layer with enhanced stability was introduced by chemical crosslinking to eliminate the expansion of inner core and the diffusion of inner content. The physicochemical structure of the double-layer hydrogels was characterized. The drug-release results demonstrated that the sustained-release effect of the hydrogels for different model drugs could be regulated by changing the composition or thickness of the hydrogel layer. The significant sustained-release effect for BSA and indomethacin indicated that the bilayer hydrogel can be developed into a novel sustained delivery system for bioactive substance or drugs with potential applications in drugs and functional foods.
登录
查看更多内容
影响因子：
11.2
作者：
Gao, Yuxue;Zong, Shiyu;Duan, Jiufang
通讯作者：
Duan, Jiufang
影响因子：
11.2
作者：
Bruchet, Marion;Melman, Artem
通讯作者：
Melman, Artem
影响因子：
5.8
作者：
Hu, Yan;Zhou, Xiaoju;Hu, Xianming
通讯作者：
Hu, Xianming
基于带相反电荷多糖的自组装聚电解质复合水凝胶的构建用于绿茶多酚的持续递送
影响因子：
8.8
作者：
Hu, Xinyu;Wang, Yongmei;Xu, Man
通讯作者：
Xu, Man
DOI：
10.1016/j.ejpb.2009.07.008
发表时间：
2009-11-01
影响因子：
4.9
作者：
Colinet, I.;Dulong, V.;Le Cerf, D.
通讯作者：
Le Cerf, D.