Interactions between innate immunity and insulin signaling affect resistance to infection in insects.
Interactions between innate immunity and insulin signaling affect resistance to infection in insects.
复制标题
DOI：
10.3389/fimmu.2023.1276357
复制
发表时间：
2023
影响因子：
7.3
通讯作者：
Lazzaro, Brian P.
中科院分区：
文献类型：
--
作者：
Darby, Andrea M.;Lazzaro, Brian P.
关键词：
主动免疫应答需要能量，并且需要重新分配营养以支持对感染的抵抗和耐受。胰岛素信号传导是代谢和全身稳态的关键全局调节剂，以响应营养可用性和能量需求，包括动员能量以支持免疫系统所需的那些。在这篇综述中，我们分享的研究结果表明，先天免疫活性和胰岛素信号之间的相互作用，主要是在昆虫模型果蝇以及其他昆虫，如家蚕和按蚊蚊子。这些研究表明，胰岛素信号传导和先天免疫激活相互影响，但这些影响取决于病原体的类型，感染途径和宿主的营养状况。未来的研究将需要进一步了解先天免疫和胰岛素信号传导活动相互影响的详细机制。
An active immune response is energetically demanding and requires reallocation of nutrients to support resistance to and tolerance of infection. Insulin signaling is a critical global regulator of metabolism and whole-body homeostasis in response to nutrient availability and energetic needs, including those required for mobilization of energy in support of the immune system. In this review, we share findings that demonstrate interactions between innate immune activity and insulin signaling primarily in the insect model Drosophila melanogaster as well as other insects like Bombyx mori and Anopheles mosquitos. These studies indicate that insulin signaling and innate immune activation have reciprocal effects on each other, but that those effects vary depending on the type of pathogen, route of infection, and nutritional status of the host. Future research will be required to further understand the detailed mechanisms by which innate immunity and insulin signaling activity impact each other.
登录
查看更多内容
影响因子：
6.7
作者：
Binggeli O;Neyen C;Poidevin M;Lemaitre B
通讯作者：
Lemaitre B
影响因子：
3.7
作者：
Erkosar B;Defaye A;Bozonnet N;Puthier D;Royet J;Leulier F
通讯作者：
Leulier F
影响因子：
2.7
作者：
Marquez, Alexander G.;Pietri, Jose E.;Smithers, Hannah M.;Nuss, Andrew;Antonova, Yevgeniya;Drexler, Anna L.;Riehle, Michael A.;Brown, Mark R.;Luckhart, Shirley
通讯作者：
Luckhart, Shirley
影响因子：
13.6
作者：
Chatterjee N;Perrimon N
通讯作者：
Perrimon N
影响因子：
64.5
作者：
Böhni, R;Riesgo-Escovar, J;Hafen, E
通讯作者：
Hafen, E