Development of biomimetic thermoplastic polyurethane/fibroin small-diameter vascular grafts via a novel electrospinning approach.
Development of biomimetic thermoplastic polyurethane/fibroin small-diameter vascular grafts via a novel electrospinning approach.
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DOI：
10.1002/jbm.a.36297
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发表时间：
2018-04
期刊：
影响因子：
--
通讯作者：
Turng LS
中科院分区：
文献类型：
--
作者：
Yu E;Mi HY;Zhang J;Thomson JA;Turng LS
一种新的静电纺丝方法用于制造具有类似于天然弹性组织的分层、周向排列和微波浪纤维结构的血管移植物。定制的静电纺丝收集器能够使用动态“跳绳”收集过程产生波浪纤维，这也解决了芯轴型收集器的样品移除问题。在这项研究中，天然丝素蛋白和合成热塑性聚氨酯（TPU）以不同的重量比组合，以产生混合小直径血管移植物。结合这两种材料的目的是利用这些天然和合成材料的生物活性和可调机械性能。结果表明，材料组成和溶剂对静电纺丝纤维形态有很大影响。所有的TPU/丝心蛋白混合移植物具有与天然血管相当的机械性能。周向排列和波浪状仿生构型为移植物提供了足够的脚趾区域和在反复扩张和收缩下长期使用的能力。人内皮细胞（EC）的细胞培养试验也显示这些移植物具有高细胞活力和良好的生物相容性。
A new electrospinning approach for fabricating vascular grafts with a layered, circumferentially aligned, and micro-wavy fibrous structure similar to natural elastic tissues has been developed. The customized electrospinning collector was able to generate wavy fibers using the dynamic “jump rope” collecting process, which also solved the sample removal problem for mandrel-type collectors. In this study, natural silk fibroin and synthetic thermoplastic polyurethane (TPU) were combined at different weight ratios to produce hybrid small-diameter vascular grafts. The purpose of combining these two materials was to leverage the bioactivity and tunable mechanical properties of these natural and synthetic materials. Results showed that the electrospun fiber morphology was highly influenced by the material compositions and solvents employed. All of the TPU/fibroin hybrid grafts had mechanical properties comparable to natural blood vessels. The circumferentially aligned and wavy biomimetic configuration provided the grafts with a sufficient toe region and the capacity for long-term usage under repeated dilatation and contraction. Cell culture tests with human endothelial cells (EC) also revealed high cell viability and good biocompatibility for these grafts.
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DOI：
10.1016/j.msec.2006.05.019
发表时间：
2007-04-01
期刊：
MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS
影响因子：
--
作者：
Lannutti, J.;Reneker, D.;Farson, D. F.
通讯作者：
Farson, D. F.
影响因子：
4
作者：
McClure, M. J.;Sell, S. A.;Bowlin, G. L.
通讯作者：
Bowlin, G. L.
影响因子：
4.2
作者：
Mi, Hao-Yang;Jing, Xin;Turng, Lih-Sheng
通讯作者：
Turng, Lih-Sheng
影响因子：
2.5
作者：
Mi, Hao-Yang;Jing, Xin;Turng, Lih-Sheng
通讯作者：
Turng, Lih-Sheng
影响因子：
14
作者：
Mooney, DT;Mazzoni, CL;Langer, R
通讯作者：
Langer, R