Factors modulating the incubation of drug and non-drug craving and their clinical implications.
Factors modulating the incubation of drug and non-drug craving and their clinical implications.
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DOI：
10.1016/j.neubiorev.2021.09.050
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发表时间：
2021-12
影响因子：
8.2
通讯作者：
Caprioli D
中科院分区：
文献类型：
--
作者：
Venniro M;Reverte I;Ramsey LA;Papastrat KM;D'Ottavio G;Milella MS;Li X;Grimm JW;Caprioli D
1986年有人提出，在早期戒断期间，线索诱导的可卡因渴望逐渐增加，并在较长时间内保持较高水平。临床证据现在支持这一假设，这种增加并不是可卡因特有的，而是在几种滥用药物中普遍存在的。研究人员在啮齿动物中发现了类似的潜伏现象，在静脉注射药物或美味食物自我给药后，观察到线索诱导的药物寻求的时间依赖性增加。渴望的潜伏期易受个体周围的生物和/或环境条件的影响而变化。在过去的十年中，神经生物学的相关性的调制作用的生物（性别，年龄，遗传因素）和环境因素（环境丰富和体育锻炼，睡眠结构，急性和慢性压力，禁欲强化程序）对孵化的药物渴求进行了研究。在这篇综述中，我们总结了这些研究所采用的行为程序，关键的潜在神经生物学相关性和临床意义。
It was suggested in 1986 that cue-induced cocaine craving increases progressively during early abstinence and remains high during extended periods of time. Clinical evidence now supports this hypothesis and that this increase is not specific to cocaine but rather generalize across several drugs of abuse. Investigators have identified an analogous incubation phenomenon in rodents, in which time-dependent increases in cue-induced drug seeking are observed after abstinence from intravenous drug or palatable food self-administration. Incubation of craving is susceptible to variation in magnitude as a function of biological and/or the environmental circumstances surrounding the individual. During the last decade, the neurobiological correlates of the modulatory role of biological (sex, age, genetic factors) and environmental factors (environmental enrichment and physical exercise, sleep architecture, acute and chronic stress, abstinence reinforcement procedures) on incubation of drug craving has been investigated. In this review, we summarized the behavioral procedures adopted, the key underlying neurobiological correlates and clinical implications of these studies.
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