Calcium signaling in mammalian egg activation and embryo development: the influence of subcellular localization.
Calcium signaling in mammalian egg activation and embryo development: the influence of subcellular localization.
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DOI：
10.1002/mrd.22078
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发表时间：
2012-11
影响因子：
2.5
通讯作者：
Williams, Carmen J.
中科院分区：
文献类型：
--
作者：
Miao, Yi-Liang;Williams, Carmen J.
Calcium (Ca2+) signals drive the fundamental events surrounding fertilization and the activation of development in all species examined to date. Initial studies of Ca2+ signaling at fertilization in marine animals were tightly linked to new discoveries of bioluminescent proteins and their use as fluorescent Ca2+ sensors. Since that time, there has been rapid progress in our understanding of the key functions for Ca2+ in many cell types and the impact of cellular localization on Ca2+ signaling pathways. In this review, which focuses on mammalian egg activation, we consider how Ca2+ is regulated and stored at different stages of oocyte development and examine the functions of molecules that serve as both regulators of Ca2+ release and effectors of Ca2+ signals. We then summarize studies exploring how Ca2+ directs downstream effectors mediating both egg activation and later signaling events required for successful preimplantation embryo development. Throughout this review, we focus attention on how localization of Ca2+ signals influences downstream signaling events, and attempt to highlight gaps in our knowledge that are ripe areas for future research.
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影响因子：
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通讯作者：
Schulman, H
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