Environmental Obesogens: Mechanisms and Controversies.
Environmental Obesogens: Mechanisms and Controversies.
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DOI：
10.1146/annurev-pharmtox-010818-021304
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发表时间：
2019-01-06
影响因子：
12.5
通讯作者：
Blumberg B
中科院分区：
文献类型：
--
作者：
Heindel JJ;Blumberg B
肥胖在全球成人和儿童中普遍存在，并且由于其与 2 型糖尿病、代谢综合征、心血管疾病和癌症的相关性而大大增加了医疗费用。对于肥胖的流行医学观点认为，肥胖是由热量摄入和能量消耗之间的简单不平衡造成的。然而，许多其他因素在肥胖的病因学中也很重要。致肥胖假说提出，被称为“致肥胖物”的环境化学物质通过改变代谢设定点或改变食欲和饱腹感的激素调节来增加脂肪细胞的定向、分化和大小，从而促进肥胖。许多致肥胖物质是内分泌干扰化学物质，会干扰正常的内分泌调节。我们的环境中存在大量干扰内分泌的肥胖物质，用于从食品包装到杀菌剂的日常产品中。这篇综述探讨了支持致肥胖假说的证据，以及目前阻碍我们全面了解致肥胖因素对肥胖流行的影响程度的知识差距。
Obesity is worldwide pandemic in adults as well as children and adds greatly to healthcare costs through its association with type 2 diabetes, metabolic syndrome, cardiovascular disease and cancers. The prevailing medical view of obesity is that it results from a simple imbalance between caloric intake and energy expenditure. However, numerous other factors are important in the etiology of obesity. The Obesogen Hypothesis proposes that environmental chemicals, termed “obesogens,” promote obesity by acting to increase adipocyte commitment, differentiation and size, by altering metabolic setpoints or altering the hormonal regulation of appetite and satiety. Many obesogens are endocrine disrupting chemicals that interfere with normal endocrine regulation. Endocrine disrupting obesogens are abundant in our environment, used in everyday products from food packaging to fungicides. This review explores the evidence supporting the obesogen hypothesis, as well as the gaps in our knowledge that are currently preventing a complete understanding of the extent to which obesogens contribute to the obesity pandemic.
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DOI：
10.1038/nrendo.2016.186
发表时间：
2017-03
期刊：
Nature reviews. Endocrinology
影响因子：
--
作者：
Braun JM
通讯作者：
Braun JM
影响因子：
11.8
作者：
Barouki R;Melén E;Herceg Z;Beckers J;Chen J;Karagas M;Puga A;Xia Y;Chadwick L;Yan W;Audouze K;Slama R;Heindel J;Grandjean P;Kawamoto T;Nohara K
通讯作者：
Nohara K
影响因子：
8.8
作者：
Darbre PD
通讯作者：
Darbre PD
影响因子：
120.7
作者：
Dabelea, Dana;Mayer-Davis, Elizabeth J.;Saydah, Sharon;Imperatore, Giuseppina;Linder, Barbara;Divers, Jasmin;Bell, Ronny;Badaru, Angela;Talton, Jennifer W.;Crume, Tessa;Liese, Angela D.;Merchant, Anwar T.;Lawrence, Jean M.;Reynolds, Kristi;Dolan, Lawrence;Liu, Lenna L.;Hamman, Richard F.
通讯作者：
Hamman, Richard F.
影响因子：
9.8
作者：
Braun JM;Gray K
通讯作者：
Gray K