Longitudinal associations between circulating interleukin-6 and C-reactive protein in childhood, and eating disorders and disordered eating in adolescence.
Longitudinal associations between circulating interleukin-6 and C-reactive protein in childhood, and eating disorders and disordered eating in adolescence.
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DOI：
10.1016/j.bbi.2020.07.040
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发表时间：
2020-10
期刊：
影响因子：
--
通讯作者：
Lewis G
中科院分区：
文献类型：
--
作者：
Solmi F;Bulik CM;De Stavola BL;Dalman C;Khandaker GM;Lewis G
9岁时的IL 6水平与14岁、16岁和18岁时的进食障碍无关。9岁时较低的CRP水平与青春期更严重的饮食失调有关。我们观察到的相关性较弱，不能排除残留混杂因素。很少有研究探讨炎症和饮食失调之间的联系，也没有使用纵向设计。我们在一个大的普通人群样本中调查了儿童期血清白细胞介素6（IL-6）和C反应蛋白（CRP）水平与青少年期进食障碍及相关行为和认知之间的关系。我们使用的数据来自雅芳家长和孩子纵向研究（ALSPAC）。我们的暴露量是来自9岁时血清测量的IL 6和CRP的三分之一，结果是14岁，16岁和18岁时的饮食失调诊断和自我报告的饮食失调行为。我们使用单变量和多变量多水平逻辑回归模型，调整了一些潜在的混杂因素，包括性别、脂肪量和预先存在的心理健康问题。我们的样本包括3480名儿童。在调整混杂因素后，CRP水平前三分之一的人暴饮暴食（比值比（OR）：0.62，95%可信区间（CI）：0.39，1.00，p“等于”0.05）和空腹（OR：0.63，95% CI：0.38，1.07，p“等于”0.09）的几率较低。我们还观察到与泻药、神经性厌食症和神经性贪食症之间存在类似程度的弱相关性。我们没有发现IL 6水平与任何研究结果之间存在任何关联。几乎没有证据表明CRP和IL-6与青少年进食障碍结局之间存在关联。观察到CRP和暴饮暴食之间的负相关性是出乎意料的，因此在解释它时需要谨慎。一种可能的解释是，较高的CRP水平可能通过影响食欲特征对饮食失调起到保护作用。
Levels of IL6 at 9 years were not associated with eating disorders at 14, 16, and 18. Lower CRP levels at 9 were associated with greater disordered eating in adolescence. The associations we observed were weak and residual confounding cannot be excluded. Few studies have explored the association between inflammation and eating disorders and none used a longitudinal design. We investigated the association between serum-levels of interleukin 6 (IL-6) and C-reactive protein (CRP) measured in childhood and eating disorders and related behaviours and cognitions in adolescence in a large general population sample. We used data from the Avon Longitudinal Study of Parents and Children (ALSPAC). Our exposures were thirds of IL6 and CRP derived from serum measurements taken at age nine years, and outcomes were eating disorder diagnoses and self-reported disordered eating behaviours at ages 14, 16, and 18 years. We used univariable and multivariable multilevel logistic regression models adjusting for a number of potential confounders, including sex, fat mass, and pre-existing mental health difficulties. Our sample included 3480 children. Those in the top third of CRP had lower odds of binge eating (odds ratio(OR):0.62, 95% confidence interval (CI):0.39,1.00,p “equals” 0.05) and fasting (OR:0.63, 95% CI:0.38,1.07,p “equals” 0.09) after adjustment for confounders. We also observed weak associations of comparable magnitude for purging, anorexia nervosa, and bulimia nervosa. We did not find any associations between levels of IL6 and any of the outcomes under study. There was little evidence of an association between CRP and IL-6 and adolescent eating disorder outcomes. The inverse association observed between CRP and binge eating was unexpected, so caution is needed when interpreting it. One possible explanation is that higher CRP levels could have a protective role for disordered eating by affecting appetitive traits.
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