Working Memory 2.0.

Working Memory 2.0.
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DOI:
10.1016/j.neuron.2018.09.023
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发表时间:
2018-10-24
期刊:
影响因子:
16.2
通讯作者:
Bastos AM
Bastos AM
中科院分区:
医学1区
文献类型:
--
作者:
Miller EK;Lundqvist M;Bastos AM

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工作记忆(WM)是我们摆脱反射性输入-输出反应以控制自己思想的基本功能。它有两种类型的机制:信息的在线维护和其意志或执行控制。经典模型提出了持久的峰值维护,但没有明确地解决执行控制。我们回顾了最近的理论和实证研究,这些研究建议对经典模型进行更新/补充。突触权值在稀疏脉冲间的变化加强了WM的维持。执行控制通过皮层表层(第2层和第3层)的伽马(30-100 Hz)和皮层深层(第5层和第6层)的α / β (10-30 Hz)网络振荡之间的相互作用起作用。深层α / β与自上而下的信息和抑制有关。它调节与浅层伽马有关的自下而上的感觉信息的流动。我们提出,不同皮层层中不同节律之间的相互作用是WM维持及其意志控制的基础。Miller等人提出了一种新的工作记忆模型。突触权值在稀疏尖峰之间的变化有助于增强WM的维持。不同皮质层的α / β和γ节律之间的相互作用为其意志控制提供了基础设施。
Working memory (WM) is the fundamental function by which we break free from reflexive input-output reactions to gain control over our own thoughts. It has two types of mechanisms: online maintenance of information and its volitional or executive control. Classic models proposed persistent spiking for maintenance but have not explicitly addressed executive control. We review recent theoretical and empirical studies that suggest updates/additions to the classic model. Synaptic weight changes between sparse bursts of spiking strengthen WM maintenance. Executive control acts via interplay between network oscillations in gamma (30-100 Hz) in superficial cortical layers (layers 2 & 3) and alpha/beta (10-30 Hz) in deep cortical layers (layers 5 & 6). Deep-layer alpha/beta is associated with top-down information and inhibition. It regulates the flow of bottom-up sensory information associated with superficial layer gamma. We propose that interactions between different rhythms in distinct cortical layers underlie WM maintenance and its volitional control. Miller et al present a new model of working memory (WM). Synaptic weight changes between sparse spiking help strengthen WM maintenance. Interplay between alpha/beta and gamma rhythms in different cortical layers provide an infrastructure for its volitional control.
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