Uncovering neurodevelopmental windows of susceptibility to manganese exposure using dentine microspatial analyses.
Uncovering neurodevelopmental windows of susceptibility to manganese exposure using dentine microspatial analyses.
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DOI：
10.1016/j.envres.2017.12.003
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发表时间：
2018-03
影响因子：
8.3
通讯作者：
Arora M
中科院分区：
文献类型：
--
作者：
Claus Henn B;Austin C;Coull BA;Schnaas L;Gennings C;Horton MK;Hernández-Ávila M;Hu H;Téllez-Rojo MM;Wright RO;Arora M
锰（Mn）与神经发育之间的关系可能取决于剂量和暴露时间，但大多数研究不能很好地测量随时间的暴露变异性。我们使用具有时间信息的牙齿基质生物标志物来揭示早期生活中Mn与儿童视觉运动能力相关的易感性窗口。我们还探讨了铅（Pb）和儿童性别对效果的影响。参与者来自ELEMENT（墨西哥早期生活暴露和神经毒理学）纵向出生队列研究。采用激光消融-电感耦合等离子体质谱法分析138例儿童乳牙，重建了产前和产后早期锰、铅暴露的剂量和时间。神经发育在6-16岁之间进行评估，使用宽范围视觉运动能力评估（WRAVMA）。用多变量广义加性混合模型估计Mn与WRAVMA总分和子量表的关联。我们在分层模型中研究了锰与铅和儿童性别的相互作用。牙质锰水平在妊娠中期最高，在产前期间急剧下降，出生后下降速度较慢。在较低（<中位）牙齿铅水平的儿童中，Mn与妊娠中期的视觉空间和总WRAVMA评分呈正相关：在出产前150天，Mn转化的牙质增加一个标准差（SD）与总评分增加0.15 [95% CI: 0.04, 0.26] SD相关。在高铅水平下没有观察到这种正相关。与产前相比，仅在男孩中，出生后6至12个月期间发现了显著的负相关：Mn转化的牙本质每增加一个SD，与视觉空间评分的0.11 [95% CI:−0.001,−0.22]至0.16 [95% CI:−0.04,−0.28]SD下降相关。使用具有精细暴露时间分布的牙齿基质生物标志物，我们发现了离散的发育窗口，其中Mn与视觉空间能力相关。我们的研究结果表明，锰的关联在很大程度上是由暴露时间驱动的，在产前水平发现有益的影响，在产后水平发现有毒的影响。
Associations between manganese (Mn) and neurodevelopment may depend on dose and exposure timing, but most studies cannot measure exposure variability over time well. We apply temporally informative tooth-matrix biomarkers to uncover windows of susceptibility in early life when Mn is associated with visual motor ability in childhood. We also explore effect modification by lead (Pb) and child sex. Participants were drawn from the ELEMENT (Early Life Exposures in MExico and NeuroToxicology) longitudinal birth cohort studies. We reconstructed dose and timing of prenatal and early postnatal Mn and Pb exposures for 138 children by analyzing deciduous teeth using laser ablation-inductively coupled plasma-mass spectrometry. Neurodevelopment was assessed between 6–16 years of age using the Wide Range Assessment of Visual Motor Abilities (WRAVMA). Mn associations with total WRAVMA scores and subscales were estimated with multivariable generalized additive mixed models. We examined Mn interactions with Pb and child sex in stratified models. Levels of dentine Mn were highest in the second trimester and declined steeply over the prenatal period, with a slower rate of decline after birth. Mn was positively associated with visual spatial and total WRAVMA scores in the second trimester, among children with lower (<median) tooth Pb levels: one standard deviation (SD) increase in ln-transformed dentine Mn at 150 days before birth was associated with a 0.15 [95% CI: 0.04, 0.26] SD increase in total score. This positive association was not observed at high Pb levels. In contrast to the prenatal period, significant negative associations were found in the postnatal period from ~6 to 12 months of age, among boys only: one SD increase in ln-transformed dentine Mn was associated with a 0.11 [95% CI: −0.001, −0.22] to 0.16 [95% CI: −0.04, −0.28] SD decrease in visual spatial score. Using tooth-matrix biomarkers with fine scale temporal profiles of exposure, we found discrete developmental windows in which Mn was associated with visual-spatial abilities. Our results suggest that Mn associations are driven in large part by exposure timing, with beneficial effects found for prenatal levels and toxic effects found for postnatal levels.
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影响因子：
8.3
作者：
Chiu YM;Claus Henn B;Hsu HL;Pendo MP;Coull BA;Austin C;Cagna G;Fedrighi C;Placidi D;Smith DR;Wright RO;Lucchini RG;Arora M
通讯作者：
Arora M
影响因子：
6.1
作者：
Cordova FM;Aguiar AS Jr;Peres TV;Lopes MW;Gonçalves FM;Pedro DZ;Lopes SC;Pilati C;Prediger RD;Farina M;Erikson KM;Aschner M;Leal RB
通讯作者：
Leal RB
影响因子：
9.8
作者：
Arora, Manish;Kennedy, Brendan J.;Chan, Sheena W. Y.
通讯作者：
Chan, Sheena W. Y.
DOI：
10.1016/j.etp.2012.02.006
发表时间：
2013-07
期刊：
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
影响因子：
--
作者：
Calderón-Garcidueñas L;Serrano-Sierra A;Torres-Jardón R;Zhu H;Yuan Y;Smith D;Delgado-Chávez R;Cross JV;Medina-Cortina H;Kavanaugh M;Guilarte TR
通讯作者：
Guilarte TR
影响因子：
11.4
作者：
Gunier, Robert B.;Bradman, Asa;Jerrett, Michael;Smith, Donald R.;Harley, Kim G.;Austin, Christine;Vedar, Michelle;Arora, Manish;Eskenazi, Brenda
通讯作者：
Eskenazi, Brenda