Long-latency suppression of auditory and somatosensory change-related cortical responses.
Long-latency suppression of auditory and somatosensory change-related cortical responses.
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DOI：
10.1371/journal.pone.0199614
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Nishihara M
中科院分区：
文献类型：
--
作者：
Takeuchi N;Sugiyama S;Inui K;Kanemoto K;Nishihara M
感觉抑制是一种减弱选择性信息的机制。至于听觉和躯体感觉系统中的长潜伏期抑制，成对脉冲抑制，作为间隔约500 ms的2个相同刺激被观察到，是众所周知的，尽管其机制仍有待阐明。在本研究中，我们使用脑磁图研究了听觉和体感变化相关皮层反应的长潜伏期抑制之间的关系。躯体感觉变化相关的反应诱发的刺激强度突然增加，在100 Hz的电流恒定的方波脉冲的列车在手腕的左正中神经。此外，听觉变化相关的反应引起的声压增加了15分贝，在一个连续的声音组成的一列25毫秒的纯音。在实验1中使用双耳刺激，而在实验2中使用单耳刺激。对于躯体感觉和听觉刺激，条件反射和测试刺激是相同的，并插入在2400和3000毫秒，分别。结果表明，在双侧Parisylvian区的测试反应明显抑制，但不是在对侧半球的中央后回的躯体感觉系统。同样，双侧颞上平面（N100m）的测试反应在听觉系统中也受到抑制。此外，右N100 m和右Parisylvian活动的抑制之间存在显著相关性，表明两者涉及类似的机制。最后，一个高的重测信度的抑制被认为是与这两种方式。在本研究中揭示的抑制被认为是反映了个体受试者的感觉抑制能力。
Sensory suppression is a mechanism that attenuates selective information. As for long-latency suppression in auditory and somatosensory systems, paired-pulse suppression, observed as 2 identical stimuli spaced by approximately 500 ms, is widely known, though its mechanism remains to be elucidated. In the present study, we investigated the relationship between auditory and somatosensory long-latency suppression of change-related cortical responses using magnetoencephalography. Somatosensory change-related responses were evoked by an abrupt increase in stimulus strength in a train of current-constant square wave pulses at 100 Hz to the left median nerve at the wrist. Furthermore, auditory change-related responses were elicited by an increase in sound pressure by 15 dB in a continuous sound composed of a train of 25-ms pure tones. Binaural stimulation was used in Experiment 1, while monaural stimulation was used in Experiment 2. For both somatosensory and auditory stimuli, the conditioning and test stimuli were identical, and inserted at 2400 and 3000 ms, respectively. The results showed clear suppression of the test response in the bilateral parisylvian region, but not in the postcentral gyrus of the contralateral hemisphere in the somatosensory system. Similarly, the test response in the bilateral supratemporal plane (N100m) was suppressed in the auditory system. Furthermore, there was a significant correlation between suppression of right N100m and right parisylvian activity, suggesting that similar mechanisms are involved in both. Finally, a high test-retest reliability for suppression was seen with both modalities. Suppression revealed in the present study is considered to reflect sensory inhibition ability in individual subjects.
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