Predictors of endothelial function in employees with sedentary occupations in a worksite exercise program.
Predictors of endothelial function in employees with sedentary occupations in a worksite exercise program.
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DOI：
10.1016/j.amjcard.2008.05.020
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发表时间：
2008-10-01
影响因子：
2.8
通讯作者：
Cannon, Richard O., III
中科院分区：
文献类型：
--
作者：
Lippincott, Margaret F.;Desai, Aditi;Zalos, Gloria;Carlow, Andrea;De Jesus, Janet;Blum, Arnon;Smith, Kevin;Rodrigo, Maria;Patibandla, Sushmitha;Chaudhry, Hira;Glaser, Alexander P.;Schenke, William H.;Csako, Gyorgy;Waclawiw, Myron A.;Cannon, Richard O., III
久坐不动的工作人员将来患心血管疾病的风险可能会增加。人们提倡在工作场所进行锻炼，但对作为风险生物标志物的内皮细胞的影响以及与体重减轻、脂质改变或循环内皮祖细胞（EPCs）的关系尚未见报道。72名办公室和实验室员工（26名身体质量指数[BMI] bbb30 kg/m2）（58名女性，平均年龄45岁，范围22-62岁）完成了为期3个月的参与国家心肺血液研究所的“保持跳动”计划，确定了生命体征，实验室数据和跑步机运动时的峰值耗氧量（VO2）。肱动脉内皮通过血流介导扩张（FMD）检测，其在基线时与Framingham风险评分呈负相关（r=-0.3689， P<0.0001）。用集落法定量EPCs。每周平均运动98±47分钟（平均±SD）， FMD（从7.8±3.4到8.5±3.0%，P=0.0096）和峰值VO2（+1.2±3.1 mL O2/kg/min， P=0.0028）改善，舒张压（-2±8 mmHg， P=0.0478），总胆固醇（-8±25 mg/dL， P=0.0131），低密度脂蛋白（LDL）胆固醇（-7±19 mg/dL， P=0.0044）降低，但体重略有减少（-0.5±2.1 kg， P=0.0565）。通过多元回归模型，较低的基线FMD、较大的年龄、总胆固醇和低密度脂蛋白胆固醇和舒张压的降低，以及EPC菌落和峰值VO2的增加是FMD变化的统计学显著预测因素，占FMD改善的47%。当只对女性进行建模时，结果相似。相比之下，基线肥胖和体重变化都不是内皮功能改善的预测因素。总之，从事久坐工作的员工每天在工作场所进行的锻炼可以改善内皮功能——即使没有减轻体重——如果持续下去，这可能会降低心血管风险。
A sedentary work force may be at increased risk of future cardiovascular disease. Exercise at the worksite has been advocated, but effects on endothelium as a biomarker of risk and relation to weight loss, lipid changes or circulating endothelial progenitor cells (EPCs) have not been reported. Seventy-two office and laboratory (26 with body-mass index [BMI] > 30 kg/m2) employees (58 women; average age 45 years; range: 22-62 years) completed 3 months of participation in the National Heart, Lung, and Blood Institute's “Keep the Beat” program, with determination of vital signs, laboratory data and peak oxygen consumption (VO2) during treadmill exercise. Brachial artery endothelium was tested by flow-mediated dilation (FMD), which at baseline was inversely associated with Framingham risk score (r=-0.3689, P<0.0001). EPCs were quantified by colony assay. With exercise averaging 98±47 (mean±SD) minutes each work week, there was improvement in FMD (from 7.8±3.4 to 8.5±3.0%, P=0.0096) and peak VO2 (+1.2±3.1 mL O2/kg/min; P=0.0028), with reduction in diastolic blood pressure (-2±8 mmHg; P=0.0478), total cholesterol (-8±25 mg/dL, P=0.0131), low-density lipoprotein (LDL) cholesterol (-7±19 mg/dL, P=0.0044), but with marginal reduction in weight (-0.5±2.1 kg, P=0.0565). By multiple regression modeling, lower baseline FMD, greater age, reductions in total and LDL cholesterol and diastolic blood pressure, and increases in EPC colonies and peak VO2 were jointly statistically significant predictors of change in FMD and accounted for 47% of the variability in FMD improvement with program participation. Results were similar when modeling was performed for women only. By contrast, neither adiposity at baseline nor change in weight were predictors of improved endothelial function. In conclusion, daily exercise achievable in the worksite by employees with sedentary occupations improves endothelial function—even with absence of weight loss--which may decrease cardiovascular risk, if sustained.
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影响因子：
5.3
作者：
Steiner, S;Niessner, A;Kopp, CW
通讯作者：
Kopp, CW
影响因子：
5.5
作者：
Dishman, RK;Oldenburg, B;Shephard, RJ
通讯作者：
Shephard, RJ
DOI：
10.1161/01.atv.0000140199.14930.32
发表时间：
2004-10-01
影响因子：
8.7
作者：
Okita, K;Nishijima, H;Kitabatake, A
通讯作者：
Kitabatake, A
影响因子：
24
作者：
Rehman, J;Li, JL;March, KL
通讯作者：
March, KL
影响因子：
8.2
作者：
MATTHEWS, DR;HOSKER, JP;TURNER, RC
通讯作者：
TURNER, RC