Effect of Oral Vitamin D3 on Dental Caries: An In-Vivo and In-Vitro Study.
Effect of Oral Vitamin D3 on Dental Caries: An In-Vivo and In-Vitro Study.
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DOI：
10.7759/cureus.25360
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发表时间：
2022-05
影响因子：
1.2
通讯作者：
Al-Mashhadane, Faehaa Azher
中科院分区：
文献类型：
--
作者：
Al-Jubori, Sawsan Hameed;AL-Murad, Maha A.;Al-Mashhadane, Faehaa Azher
目的维生素D3在影响牙列整体矿化过程中起重要作用。补充剂的使用有助于保持最佳水平，从而减少治疗非常早期龋齿病变的机会。因此，目的是研究间接影响口服维生素D3的显微硬度和元素的重量百分比的钙（Ca）和磷（P）在釉质表面与人工引发的龋损。方法将120颗离体前磨牙随机分为5组。每组共有24名参与者，具有以下特征：对照+ve：健康牙釉质;对照-ve：仅进行pH循环; A：pH循环并浸入对照唾液; B：pH循环和三周后收集的唾液;以及C：pH循环和六周后收集唾液。成年志愿者每天服用维生素D3 1000 IU凝胶胶囊，持续6周。在每次摄入维生素D3之前，从每个参与者收集10 mL未刺激的对照唾液。另外10毫升。在接受维生素D三周和六周后收集。唾液浸泡时间（12小时）。用维氏显微硬度计和X射线荧光光谱仪对牙釉质表面进行了测试。结果所有标本在脱矿后Ca和P的重量百分比均显著降低，而在补充维生素D3后，Ca和P的重量百分比显著升高。显微硬度和元素分析提供了经证实的结果，这些结果表示为接受维生素D3剂量的组与未接受维生素D3剂量的组之间的统计学显著差异（P≤ 0.05）。结论口服维生素D3在促进釉质表面早期病变的再矿化方面具有显着的潜力，代表脱矿牙齿表面的表面显微硬度和矿物质含量（Ca和P重量%）的改善。
Aim Vitamin D3 plays an important role in affecting the overall remineralization process of the dentition. The use of supplements help to keep the levels at optimum and thus reduce the chances of treating very early lesion of caries. Hence the aim was to investigate the indirect effects of oral vitamin D3 on microhardness and elemental weight percentage of Calcium (Ca) and Phosphorous (P) in enamel surface with an artificially initiated carious lesion. Methods The 120 extracted premolars were randomly divided into five groups according to salivary immersion. Each group had a total of twenty-four participants, with the following characteristics: control +ve: sound enamel; control -ve: only subjected to pH cycle; A: pH cycle and immersion in control saliva; B: pH cycle and saliva collected after three weeks; and C: pH cycle and saliva collected after six weeks. The unstimulated saliva was collected from (40) adult volunteers receiving vitamin D3 1000IU gel capsules daily for six weeks. Before each vitamin D3 intake, 10 mL of unstimulated control saliva was collected from each participant. Then other 10 ml. were collected after three and six weeks of vitamin D receiving periods. Saliva immersion time (12 hours). Enamel surface was assessed by Vicker’s Microhardness machine and (X-ray fluorescence - XRF) spectrometer. Results For all specimens, there was a significant decrease in both (Ca and P weight %) after demineralization and then they significantly increased after receiving vitamin D3. The microhardness and elemental analysis provide confirmed results that were represented as a statistically significant difference at (P≤ 0.05) between groups that received vitamin D3 and those without vitamin D3 dosage. Conclusions Oral vitamin D3 has a significant potential in motivating remineralization of early lesions on the enamel surfaces representing improved surface microhardness and minerals content (Ca and P weight %) of demineralized tooth surfaces.
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影响因子：
4.2
作者：
Ahmadi-Motamayel, Fatemeh;Goodarzi, Mohammad Taghi;Darvishi, Mohammad
通讯作者：
Darvishi, Mohammad
影响因子：
5.9
作者：
Carvalho Silva C;Gavinha S;Manso MC;Rodrigues R;Martins S;Guimarães JT;Santos AC;Melo P
通讯作者：
Melo P
影响因子：
3.4
作者：
Tufekci, Eser;Dixon, Julian S.;Lindauer, Steven J.
通讯作者：
Lindauer, Steven J.
影响因子：
5
作者：
Khazai, Natasha;Judd, Suzanne E;Tangpricha, Vin
通讯作者：
Tangpricha, Vin
影响因子：
4.6
作者：
Singh P;Rawat A;Alwakeel M;Sharif E;Al Khodor S
通讯作者：
Al Khodor S