Prognostic impact of tumor-associated macrophage infiltration in non-small cell lung cancer: A systemic review and meta-analysis.
Prognostic impact of tumor-associated macrophage infiltration in non-small cell lung cancer: A systemic review and meta-analysis.
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肿瘤相关巨噬细胞浸润对非小细胞肺癌的预后影响：系统评价和荟萃分析
DOI：
10.18632/oncotarget.9079
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发表时间：
2016-06-07
期刊：
影响因子：
--
通讯作者：
Liu L
中科院分区：
文献类型：
--
作者：
Mei J;Xiao Z;Guo C;Pu Q;Ma L;Liu C;Lin F;Liao H;You Z;Liu L
肿瘤相关巨噬细胞（TAM）是肿瘤微环境的重要组成部分。本研究检索PubMed、Embase、科克伦图书馆和Web of Science，对20篇研究进行荟萃分析，共纳入2,572例非小细胞肺癌（NSCLC）患者，以确定TAM与NSCLC预后的关系。9项研究的联合风险比（HR）显示，肿瘤胰岛和间质中的总CD 68 + TAM密度与患者的总生存期（OS）无关。然而，4项研究的合并HR显示肿瘤胰岛中高密度的CD 68 + TAM预测较好的OS，而6项研究的合并HR显示肿瘤间质中高密度的CD 68 + TAM与较差的OS相关。CD 68 + TAM的高胰岛/间质比与较好的OS相关。肿瘤胰岛中高密度的M1 TAM与较好的OS相关，而肿瘤间质中高密度的M2 TAM预示着较差的OS。这些结果表明，尽管总CD 68 + TAM的密度与OS无关，但TAM的定位和M1/M2极化是NSCLC的潜在预后预测因子。
Tumor-associated macrophages (TAMs) are important components of cancer microenvironment. In the present study, we searched PubMed, Embase, Cochrane library and Web of Science to perform a meta-analysis of 20 studies including a total of 2,572 non-small cell lung cancer (NSCLC) patients, in order to determine the association between TAMs and NSCLC prognosis. The combined hazard ratio (HR) of 9 studies showed that the density of total CD68+ TAMs in the tumor islet and stroma was not associated with overall survival (OS) of the patients. However, the pooled HR of 4 studies showed that high density of CD68+ TAMs in the tumor islet predicted better OS, while the pooled HR of 6 studies showed that high density of CD68+ TAMs in the tumor stroma was associated with poor OS. A high islet/stroma ratio of CD68+ TAMs was associated with better OS. A high density of M1 TAMs in the tumor islet was associated with better OS, while a high density of M2 TAMs in the tumor stroma predicted poor OS. These findings suggest that, although the density of total CD68+ TAMs is not associated with OS, the localization and M1/M2 polarization of TAMs are potential prognostic predictors of NSCLC.
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