Striatal dopamine D₂/D₃ receptor binding in pathological gambling is correlated with mood-related impulsivity.
Striatal dopamine D₂/D₃ receptor binding in pathological gambling is correlated with mood-related impulsivity.
复制标题
DOI：
10.1016/j.neuroimage.2012.06.067
复制
发表时间：
2012-10-15
期刊：
影响因子：
5.7
通讯作者：
Lingford-Hughes, Anne R.
中科院分区：
文献类型：
--
作者：
Clark, Luke;Stokes, Paul R.;Wu, Kit;Michalczuk, Rosanna;Benecke, Aaf;Watson, Ben J.;Egerton, Alice;Piccini, Paola;Nutt, David J.;Bowden-Jones, Henrietta;Lingford-Hughes, Anne R.
病理性赌博（PG）是一种行为成瘾，与冲动性升高和疑似多巴胺失调有关。据报道，纹状体多巴胺D2/D3受体的可用性降低，可能构成成瘾性疾病的发病前脆弱性标志。本研究的目的是评估PG中纹状体多巴胺D2/D3受体的可用性及其与特质冲动的相关性。PG男性（n = 9）和男性健康对照（n = 9）接受[11 C]-雷氯必利正电子发射断层扫描成像，并完成UPPS-P冲动量表。与以前的药物成瘾报告相比，纹状体多巴胺D2/D3受体的可用性在两组之间没有显着差异。然而，在PG组中，情绪相关的冲动性（“紧迫性”）与[11 C]-雷氯必利结合电位呈负相关。纹状体多巴胺结合的组差异的情况下意味着行为成瘾和药物成瘾之间的区别。然而，我们的数据表明，在赌博障碍中多巴胺受体的可用性存在异质性，因此，具有高情绪相关冲动的个体可能会从基于多巴胺的药物中获得不同的益处。评估11 C-雷氯必利在病态赌博中的结合，一种假定的行为成瘾。纹状体多巴胺结合与健康对照组无组间差异。多巴胺结合与情绪相关的冲动性（“紧迫性”）呈负相关。
Pathological gambling (PG) is a behavioural addiction associated with elevated impulsivity and suspected dopamine dysregulation. Reduced striatal dopamine D2/D3 receptor availability has been reported in drug addiction, and may constitute a premorbid vulnerability marker for addictive disorders. The aim of the present study was to assess striatal dopamine D2/D3 receptor availability in PG, and its association with trait impulsivity. Males with PG (n = 9) and male healthy controls (n = 9) underwent [11C]-raclopride positron emission tomography imaging and completed the UPPS-P impulsivity scale. There was no significant difference between groups in striatal dopamine D2/D3 receptor availability, in contrast to previous reports in drug addiction. However, mood-related impulsivity (‘Urgency’) was negatively correlated with [11C]-raclopride binding potentials in the PG group. The absence of a group difference in striatal dopamine binding implies a distinction between behavioural addictions and drug addictions. Nevertheless, our data indicate heterogeneity in dopamine receptor availability in disordered gambling, such that individuals with high mood-related impulsivity may show differential benefits from dopamine-based medications. ► Assessed 11C-raclopride binding in pathological gambling, a putative behavioral addiction. ► No group difference in striatal dopamine binding from healthy controls. ► Dopamine binding negatively correlated with mood-related impulsivity (‘Urgency’).
登录
查看更多内容
影响因子：
5.7
作者：
Egerton, Alice;Shotbolt, John P.;Grasby, Paul M.
通讯作者：
Grasby, Paul M.
影响因子：
10.6
作者：
Cools, Roshan;D'Esposito, Mark
通讯作者：
D'Esposito, Mark
DOI：
10.1073/pnas.0912319107
发表时间：
2010-02-23
影响因子：
11.1
作者：
Gjedde, Albert;Kumakura, Yoshitaka;Moller, Arne
通讯作者：
Moller, Arne
影响因子：
10.6
作者：
Ersche, Karen D.;Turton, Abigail J.;Pradhan, Shachi;Bullmore, Edward T.;Robbins, Trevor W.
通讯作者：
Robbins, Trevor W.
影响因子：
5.6
作者：
Kim, Jong-Hoon;Son, Young-Don;Cho, Zang-Hee
通讯作者：
Cho, Zang-Hee