MarmoDetector: A novel 3D automated system for the quantitative assessment of marmoset behavior.
MarmoDetector: A novel 3D automated system for the quantitative assessment of marmoset behavior.
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MarmoDetector：一种新颖的 3D 自动化系统，用于定量评估狨猴的行为。
DOI：
10.1016/j.jneumeth.2019.03.016
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发表时间：
2019-07-01
影响因子：
3
通讯作者：
Mochizuki H
中科院分区：
文献类型：
--
作者：
Yabumoto T;Yoshida F;Miyauchi H;Baba K;Tsuda H;Ikenaka K;Hayakawa H;Koyabu N;Hamanaka H;Papa SM;Hirata M;Mochizuki H
Callithrix jacchus，通常被称为普通的绒猴，最近作为一种实验灵长类动物模型获得了兴趣，以更好地了解人类社会行为，结构和功能的基础。在绒猴中模拟人类神经和心理疾病可以增强从啮齿动物研究中获得的知识，用于未来的临床前研究。因此，对绒猴的行为进行全面和定量的评估至关重要。然而，监测和分析绒猴行为的系统尚未建立。在本文中，我们提出了一种新的多模式系统，MarmoDetector，在自由移动的条件下的绒猴行为的自动3D分析。MarmoDetector允许使用计算机跟踪分析技术对绒猴行为进行定量评估，该技术基于配备视频记录，红外图像和深度分析的Kinect系统。使用MarmoDetector，我们在家中的笼子里连续几天评估行为昼夜节律。此外，MarmoDetector检测到注射酒精的绒猴的急性，短暂的复杂行为。与2D记录相比，MarmoDetector可以更精确地检测活动，并且非常敏感，因为我们可以检测到由酒精引起的行为缺陷。MarmoDetector有助于快速准确地分析绒猴行为，并将加强对大脑疾病神经基础的研究。
Callithrix jacchus, generally known as the common marmoset, has recently garnered interest as an experimental primate model for better understanding the basis of human social behavior, architecture and function. Modelling human neurological and psychological diseases in marmosets can enhance the knowledge obtained from rodent research for future pre-clinical studies. Hence, comprehensive and quantitative assessments of marmoset behaviors are crucial. However, systems for monitoring and analyzing marmoset behaviors have yet to be established. In this paper, we present a novel multimodal system, MarmoDetector, for the automated 3D analysis of marmoset behavior under freely moving conditions. MarmoDetector allows the quantitative assessment of marmoset behaviors using computerised tracking analysis techniques that are based on a Kinect system equipped with video recordings, infrared images and depth analysis. Using MarmoDetector, we assessed behavioral circadian rhythms continuously over several days in home cages. In addition, MarmoDetector detected acute, transient complex behaviors of alcohol injected marmosets. Compared to 2D recording, MarmoDetector detects activities more precisely and is very sensitive as we could detect behavioral defects specifically induced by alcohol administration. MarmoDetector facilitates the rapid and accurate analysis of marmoset behavior and will enhance research on the neural basis of brain disorders.
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影响因子：
16.2
作者：
Miller CT;Freiwald WA;Leopold DA;Mitchell JF;Silva AC;Wang X
通讯作者：
Wang X
影响因子：
3
作者：
Barcia, C;De Pablos, V;Herrero, MT
通讯作者：
Herrero, MT
影响因子：
3
作者：
Prins, Noeline W.;Pohlmeyer, Eric A.;Prasad, Abhishek
通讯作者：
Prasad, Abhishek
影响因子：
2.7
作者：
Steven Tran;Gerlai, Robert
通讯作者：
Gerlai, Robert
影响因子：
3
作者：
Chassain, C;Eschalier, A;Durif, F
通讯作者：
Durif, F