Species association of hepatitis B virus (HBV) in non-human apes; evidence for recombination between gorilla and chimpanzee variants.
Species association of hepatitis B virus (HBV) in non-human apes; evidence for recombination between gorilla and chimpanzee variants.
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DOI：
10.1371/journal.pone.0033430
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Simmonds P
中科院分区：
文献类型：
--
作者：
Lyons S;Sharp C;LeBreton M;Djoko CF;Kiyang JA;Lankester F;Bibila TG;Tamoufé U;Fair J;Wolfe ND;Simmonds P
B型肝炎病毒（HBV）感染在人类中广泛分布，感染了大约三分之一的世界人口。在旧大陆猿类、大猩猩（Gorilla gorilla，大猩猩）、黑猩猩（Pan troglodytes，黑猩猩）、Pongo pygmaeus（猩猩）、Nomenastusus和Hylobates pileatus（长臂猿）以及新大陆猴Lagothrix lagotricha（长毛猴）中也检测到HBV变异体，并对其进行了遗传学表征。为了研究种属特异性和HBV在同域种猿（如中非的大猩猩和黑猩猩）之间或人与黑猩猩或大猩猩之间跨种属传播的可能性，对感染圈养野生非人灵长类动物的HBV变体进行了遗传学表征。62只黑猩猩中有9只（11.3%）和11只大猩猩中有2只（18%）感染了HBV（合并频率为15%），而其他旧大陆猴种则为阴性。从六只受感染的黑猩猩和两只大猩猩中获得了完整的基因组序列;来自P. t .ellioti的基因组序列与先前来自该亚种的特征变体分组。然而，从P. t. troglodytes HBV变体也在该分支内分组，指示亚种之间的传播，形成并系分支。这两种大猩猩病毒在遗传学上与黑猩猩和人类的变种不同，尽管其中一种病毒显示出与P.t.e.-在部分X和核心基因区域中衍生的HBV变体。这两个观察结果都提供了HBV在非人灵长类动物的不同种属和亚种之间循环的证据，这一结论与HBV基因型严格宿主特异性的假设不同。
Hepatitis B virus (HBV) infections are widely distributed in humans, infecting approximately one third of the world's population. HBV variants have also been detected and genetically characterised from Old World apes; Gorilla gorilla (gorilla), Pan troglodytes (chimpanzee), Pongo pygmaeus (orang-utan), Nomascus nastusus and Hylobates pileatus (gibbons) and from the New World monkey, Lagothrix lagotricha (woolly monkey). To investigate species-specificity and potential for cross species transmission of HBV between sympatric species of apes (such as gorillas and chimpanzees in Central Africa) or between humans and chimpanzees or gorillas, variants of HBV infecting captive wild-born non-human primates were genetically characterised. 9 of 62 chimpanzees (11.3%) and two from 11 gorillas (18%) were HBV-infected (15% combined frequency), while other Old world monkey species were negative. Complete genome sequences were obtained from six of the infected chimpanzee and both gorillas; those from P. t .ellioti grouped with previously characterised variants from this subspecies. However, variants recovered from P. t. troglodytes HBV variants also grouped within this clade, indicative of transmission between sub-species, forming a paraphyletic clade. The two gorilla viruses were phylogenetically distinct from chimpanzee and human variants although one showed evidence for a recombination event with a P.t.e.-derived HBV variant in the partial X and core gene region. Both of these observations provide evidence for circulation of HBV between different species and sub-species of non-human primates, a conclusion that differs from the hypothesis if of strict host specificity of HBV genotypes.
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影响因子：
3.7
作者：
Norder, H;Ebert, JW;Magnius, LO
通讯作者：
Magnius, LO
影响因子：
3.5
作者：
Magiorkinis, EN;Magiorkinis, GN;Hatzakis, AE
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Hatzakis, AE
影响因子：
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DOI：
10.1073/pnas.1015422108
发表时间：
2011-03-22
影响因子：
11.1
作者：
Gonder, Mary Katherine;Locatelli, Sabrina;Tishkoff, Sarah A.
通讯作者：
Tishkoff, Sarah A.
DOI：
10.1073/pnas.97.4.1661
发表时间：
2000-02-15
影响因子：
11.1
作者：
Hu, XL;Margolis, HS;Robertson, BH
通讯作者：
Robertson, BH