A parallel cholinergic brainstem pathway for enhancing locomotor drive.
A parallel cholinergic brainstem pathway for enhancing locomotor drive.
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DOI：
10.1038/nn.2548
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发表时间：
2010-06
影响因子：
25
通讯作者：
Alford, Simon
中科院分区：
文献类型：
--
作者：
Smetana, Roy;Juvin, Laurent;Dubuc, Rejean;Alford, Simon
The brainstem locomotor system is believed to be organized serially from the mesencephalic locomotor region (MLR) to reticulospinal neurons, which in turn, project to locomotor neurons in the spinal cord. In contrast, we now identify in lampreys, brainstem muscarinoceptive neurons receiving parallel inputs from the MLR and projecting back to reticulospinal cells to amplify and extend durations of locomotor output. These cells respond to muscarine with extended periods of excitation, receive direct muscarinic excitation from the MLR, and project glutamatergic excitation to reticulospinal neurons. Targeted block of muscarine receptors over these neurons profoundly reduces MLR-induced excitation of reticulospinal neurons and markedly slows MLR-evoked locomotion. Their presence forces us to rethink the organization of supraspinal locomotor control, to include a sustained feedforward loop that boosts locomotor output.
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影响因子：
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作者：
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通讯作者：
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