Oligofructose restores postprandial short-chain fatty acid levels during high-fat feeding.
Oligofructose restores postprandial short-chain fatty acid levels during high-fat feeding.
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低聚果糖可恢复高脂饮食期间餐后短链脂肪酸水平。
DOI：
10.1002/oby.23456
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发表时间：
2022-07
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
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肥胖与食用低膳食纤维的西方饮食有关，而益生元则会减轻体重。纤维诱导短链脂肪酸（SCFA）的产生，SCFA的管理是有益的宿主代谢稳态。然而，内源性SCFA信号传导在肥胖发展中的作用是有争议的。因此，本研究的主要目的是评价健康（普通饲料）、西方饮食喂养的肥胖（HFD）和低聚果糖处理的HFD喂养的（HFD+OFS）大鼠的短链脂肪酸（SCFA）产生和摄取的餐后时程。雄性Sprague-Dawley大鼠维持食物或HFD 5周，补充或不补充10%OFS 3周。分别于餐后0、2、4、6、8h取回肠、盲肠、结肠、门静脉和腔静脉测定SCFA。与瘦食物对照组相比，肥胖大鼠餐后盲肠和门静脉SCFA减少，而空腹SCFA浓度无差异。OFS补充增加了肥胖期间盲肠和门静脉中的SCFA水平。丁酸水平与门脉GLP-1和肥胖以及罗斯拜瑞氏菌相对丰度呈正相关。目前的研究表明，肥胖与SCFA产生减少有关，而OFS补充剂会增加SCFA水平。此外，餐后丁酸的产生似乎有利于宿主的能量稳态。
Obesity is associated with consumption of a western diet low in dietary fiber, while prebiotics reduce body weight. Fiber induces short-chain fatty acid (SCFA) production, and SCFA administration is beneficial to host metabolic homeostasis. However, the role of endogenous SCFA signaling in development of obesity is contentious. Therefore, the primary objective of this study is to evaluate the postprandial timecourse of short chain fatty acid (SCFA) production and uptake in healthy (chow), western diet-fed obese (HFD), and oligofructose-treated HFD-fed (HFD+OFS) rats. Male Sprague-Dawley rats were maintained on chow or HFD for 5 weeks, with or without supplementation of 10% OFS for 3 weeks. SCFAs were measured in the ileum, cecum, colon, portal vein and vena cava at 0, 2, 4, 6, and 8h postprandially. Postprandial cecal and portal vein SCFAs were decreased in obese rats compared to lean chow controls, while no differences were observed in fasting SCFA concentrations. OFS supplementation increased SCFA levels in the cecum and portal vein during obesity. Butyrate levels were positively associated with portal GLP-1 and adiposity and with Roseburia relative abundance. The current study demonstrates that obesity is associated with reduced SCFA production, and that OFS supplementation increases SCFA levels. Additionally, postprandial butyrate production appears to be beneficial to host energy homeostasis.
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影响因子：
5.2
作者：
Detman A;Laubitz D;Chojnacka A;Wiktorowska-Sowa E;Piotrowski J;Salamon A;Kaźmierczak W;Błaszczyk MK;Barberan A;Chen Y;Łupikasza E;Yang F;Sikora A
通讯作者：
Sikora A
影响因子：
4.4
作者：
Bernini, Luciana Jesus;Colado Simao, Andrea Name;Costa, Giselle Nobre
通讯作者：
Costa, Giselle Nobre
DOI：
10.1038/ismej.2012.8
发表时间：
2012-08
期刊：
The ISME journal
影响因子：
--
作者：
通讯作者：
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影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
2.1
作者：
Barczynska, Renata;Litwin, Mieczyslaw;Kapusniak, Janusz
通讯作者：
Kapusniak, Janusz