Development, validation and application of a new fornix template for studies of aging and preclinical Alzheimer's disease.
Development, validation and application of a new fornix template for studies of aging and preclinical Alzheimer's disease.
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DOI：
10.1016/j.nicl.2016.11.024
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发表时间：
2017
影响因子：
4.2
通讯作者：
Gold, Brian T.
中科院分区：
文献类型：
--
作者：
Brown, Christopher A.;Johnson, Nathan F.;Anderson-Mooney, Amelia J.;Jicha, Gregory A.;Shaw, Leslie M.;Trojanowski, John Q.;Van Eldik, Linda J.;Schmitt, Frederick A.;Smith, Charles D.;Gold, Brian T.
我们开发了一个合并的老年人穹窿模板，并证明了其效用的研究老化和临床前阿尔茨海默病（AD）。在实验1中，概率纤维束成像被用来重建穹窿在年轻人和老年人和成功的流线，然后平均在标准空间创建一个合并的模板。新的模板包括从海马结构到胼胝体下区域和丘脑/下丘脑的大部分穹窿。在实验2中，合并的模板进行了验证，作为一个适当的措施老化的研究，与手动跟踪措施的比较表明相同的空间覆盖在年轻和老年人群体。在实验3中，合并后的模板被发现优于年龄特异性模板的扩散张量成像数据的一个独立的参与者队列计算的灵敏度和特异性的措施。在实验4中，在第三个认知正常老年人独立队列中，通过新穹窿模板内的各向异性分数与AD病理学脑脊液标志物（Aβ42和t-tau/Aβ42比值）之间的相关性证明了与临床前AD的相关性。我们的新模板提供了一个适当的措施，用于在未来的研究中寻求表征与衰老和临床前AD相关的穹窿微结构改变。开发了一种新的合并的、较旧的穹窿DTI模板。证明了模板解剖学有效性、灵敏度和特异性。模板度量与阿尔茨海默病病理学相关。新的穹窿模板是衰老和阿尔茨海默氏症研究的适当工具。
We developed a merged younger-older adult template of the fornix and demonstrated its utility for studies of aging and preclinical Alzheimer's disease (AD). In Experiment 1, probabilistic tractography was used to reconstruct the fornix in younger and older adults and successful streamlines were then averaged to create a merged template in standard space. The new template includes the majority of the fornix from the hippocampal formation to the subcallosal region and the thalamus/hypothalamus. In Experiment 2, the merged template was validated as an appropriate measure for studies of aging, with comparisons against manual tracing measures indicating identical spatial coverage in younger and older adult groups. In Experiment 3, the merged template was found to outperform age-specific templates in measures of sensitivity and specificity computed on diffusion tensor imaging data of an independent participant cohort. In Experiment 4, relevance to preclinical AD was demonstrated via associations between fractional anisotropy within the new fornix template and cerebrospinal fluid markers of AD pathology (Aβ42 and the t-tau/Aβ42 ratio) in a third independent cohort of cognitively normal older adults. Our new template provides an appropriate measure for use in future studies seeking to characterize microstructural alterations in the fornix associated with aging and preclinical AD. A new merged, younger-older DTI template of the fornix was developed. Template anatomical validity, sensitivity and specificity were demonstrated. Template metrics correlate with Alzheimer's pathology. The new fornix template is an appropriate tool for aging and Alzheimer's research.
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DOI：
10.1109/isbi.2015.7163835
发表时间：
2015-04
期刊：
Proceedings. IEEE International Symposium on Biomedical Imaging
影响因子：
--
作者：
Jin Y;Shi Y;Zhan L;Thompson PM;Alzheimer’s Disease Neuroimaging Initiative (ADNI)
通讯作者：
Alzheimer’s Disease Neuroimaging Initiative (ADNI)
影响因子：
4.8
作者：
Nowrangi MA;Rosenberg PB
通讯作者：
Rosenberg PB
影响因子：
5.7
作者：
Gold, Brian T.;Powell, David K.;Andersen, Anders H.;Smith, Charles D.
通讯作者：
Smith, Charles D.
影响因子：
4.2
作者：
Gold BT;Zhu Z;Brown CA;Andersen AH;LaDu MJ;Tai L;Jicha GA;Kryscio RJ;Estus S;Nelson PT;Scheff SW;Abner E;Schmitt FA;Van Eldik LJ;Smith CD
通讯作者：
Smith CD
影响因子：
3.6
作者：
Hakun, Jonathan G.;Zhu, Zude;Johnson, Nathan F.;Gold, Brian T.
通讯作者：
Gold, Brian T.