Sub-meninges implantation reduces immune response to neural implants.
Sub-meninges implantation reduces immune response to neural implants.
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DOI：
10.1016/j.jneumeth.2013.01.020
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发表时间：
2013-04-15
影响因子：
3
通讯作者：
Rennaker, Robert L., II
中科院分区：
文献类型：
--
作者：
Markwardt, Neil T.;Stokol, Jodi;Rennaker, Robert L., II
神经接口周围的胶质疤痕形成抑制了它们从周围神经元获取可用信号的能力。为了提高神经记录性能，必须最大限度地减少炎症反应和神经胶质疤痕。先前的研究表明，脑膜衍生的细胞参与免疫反应，并且脑膜可能会在神经植入物的柄周围向下生长，从而导致神经胶质疤痕的形成。这项研究检查是否可以通过将神经探针完全放置在脑膜下方来减少神经胶质疤痕。给大鼠植入多组松散的微丝植入物，这些植入物要么完全放置在脑膜下方，要么按照常规方式植入，上端穿透脑膜，但不附着在头骨上。手术植入后4周进行组织学分析以评估神经胶质疤痕。我们的结果发现，与跨脑膜植入物相比，脑膜下植入物的反应性星形胶质细胞活性平均降低 63%。脑膜下植入物的小胶质细胞活性也有所降低。这些结果表明，将植入物与脑膜隔离的技术有可能减少封装反应，从而提高慢性记录的质量和稳定性。
Glial scar formation around neural interfaces inhibits their ability to acquire usable signals from the surrounding neurons. To improve neural recording performance, the inflammatory response and glial scarring must be minimized. Previous work has indicated that meningeally derived cells participate in the immune response, and it is possible that the meninges may grow down around the shank of a neural implant, contributing to the formation of the glial scar. This study examines whether the glial scar can be reduced by placing a neural probe completely below the meninges. Rats were implanted with sets of loose microwire implants placed either completely below the meninges or implanted conventionally with the upper end penetrating the meninges, but not attached to the skull. Histological analysis was performed 4 weeks following surgical implantation to evaluate the glial scar. Our results found that sub-meninges implants showed an average reduction in reactive astrocyte activity of 63% compared to trans-meninges implants. Microglial activity was also reduced for sub-meninges implants. These results suggest that techniques that isolate implants from the meninges offer the potential to reduce the encapsulation response which should improve chronic recording quality and stability.
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