A virtual reality-based FMRI study of reward-based spatial learning.
A virtual reality-based FMRI study of reward-based spatial learning.
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DOI：
10.1016/j.neuropsychologia.2010.05.033
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发表时间：
2010-08
期刊：
影响因子：
2.6
通讯作者：
Peterson BS
中科院分区：
文献类型：
--
作者：
Marsh R;Hao X;Xu D;Wang Z;Duan Y;Liu J;Kangarlu A;Martinez D;Garcia F;Tau GZ;Yu S;Packard MG;Peterson BS
尽管在动物和人类中，顶叶皮质在空间导航中起着中介作用，但基于奖励的空间学习的神经关联却鲜为人知。25名健康的成年人进行了一项虚拟现实功能磁共振成像任务，该任务要求学习使用迷宫外线索来导航8臂径向迷宫并找到隐藏的回报。与对照条件相比，在空间学习条件下搜索迷宫与激活颞顶区域有关，尽管不包括海马体。当通过随机化线索的空间位置使迷宫外线索导航变得不可能时，在控制条件下，获得奖励与海马体的激活有关。我们新颖的实验设计使我们能够评估在基于奖励的空间学习过程中，海马体和其他颞顶区域对搜索和奖励处理的不同贡献。这项转译研究将允许在动物和人类中进行平行研究，以建立跨物种学习系统的功能相似性；然后，动物的细胞和分子研究可能会告知操作对人类这些系统的影响，人类的功能磁共振研究可能会为动物的发现提供解释和相关性。
Although temporoparietal cortices mediate spatial navigation in animals and humans, the neural correlates of reward-based spatial learning are less well known. Twenty-five healthy adults performed a virtual-reality fMRI task that required learning to use extra-maze cues to navigate an 8-arm radial maze and find hidden rewards. Searching the maze in the spatial learning condition compared to the control conditions was associated with activation of temporoparietal regions, albeit not including the hippocampus. The receipt of rewards was associated with activation of the hippocampus in a control condition when using the extra-maze cues for navigation was rendered impossible by randomizing the spatial location of cues. Our novel experimental design allowed us to assess the differential contributions of the hippocampus and other temporoparietal areas to searching and reward processing during reward-based spatial learning. This translational research will permit parallel studies in animals and humans to establish the functional similarity of learning systems across species; cellular and molecular studies in animals may then inform the effects of manipulations on these systems in humans, and fMRI studies in humans may inform the interpretation and relevance of findings in animals.
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影响因子：
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