Remote targeted electrical stimulation.

Remote targeted electrical stimulation.
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DOI:
10.1088/1741-2552/acd95c
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发表时间:
2023-06-09
影响因子:
4
通讯作者:
--
中科院分区:
工程技术2区
文献类型:
--
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目标:在特定目标中远程产生电场的能力将改变依赖于电信号的过程的操作。方法:本文表明,通过组合两种正交的远程施加能量(磁场和聚焦超声波场),可以从远处产生聚焦电场。该效应源自应用于磁场和超声波场的洛伦兹力方程。主要结果:我们使用标准硬件引发了这种效应,并确认生成的电场与洛伦兹方程一致。该效应显着且安全地调节了人类周围神经和非人类灵长类动物的深部大脑区域。意义:这种方法开辟了一系列新的应用,其中电场在完整的生物组织或材料内以高时空分辨率产生,从而规避了传统基于电极的程序的局限性。
Objective: The ability to generate electric fields in specific targets remotely would transform manipulations of processes that rest on electrical signaling. Approach: This article shows that focal electric fields are generated from distance by combining two orthogonal, remotely applied energies—magnetic and focused ultrasonic fields. The effect derives from the Lorentz force equation applied to magnetic and ultrasonic fields. Main results: We elicited this effect using standard hardware and confirmed that the generated electric fields align with the Lorentz equation. The effect significantly and safely modulated human peripheral nerves and deep brain regions of non-human primates. Significance: This approach opens a new set of applications in which electric fields are generated at high spatiotemporal resolution within intact biological tissues or materials, thus circumventing the limitations of traditional electrode-based procedures.
DOI: 10.1111/ner.12100
发表时间: 2014-04
期刊: Neuromodulation : journal of the International Neuromodulation Society
影响因子: --
作者:
Kilgore KL;Bhadra N
通讯作者: Bhadra N
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发表时间: 1978-01-01
影响因子: 2.4
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