Evolutionary analyses of genes in Echinodermata offer insights towards the origin of metazoan phyla.
Evolutionary analyses of genes in Echinodermata offer insights towards the origin of metazoan phyla.
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棘皮动物门基因的进化分析为后生动物门的起源提供了新的见解。
DOI:
10.1016/j.ygeno.2022.110431
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发表时间:
2022-07
期刊:
影响因子:
4.4
通讯作者:
Hinman, Veronica F.
中科院分区:
文献类型:
--
作者:
Foley, Saoirse;Vlasova, Anna;Marcet-Houben, Marina;Gabaldon, Toni;Hinman, Veronica F.
Despite recent studies discussing the evolutionary impacts of gene duplications and losses among metazoans, the genomic basis for the evolution of phyla remains enigmatic. Here, we employ phylogenomic approaches to search for orthologous genes without known functions among echinoderms, and subsequently use them to guide the identification of their homologs across other metazoans. Our final set of 14 genes was obtained via a suite of homology prediction tools, gene expression data, gene ontology, and generating the Strongylocentrotus purpuratus phylome. The gene set was subjected to selection pressure analyses, which indicated that they are highly conserved and under negative selection. Their presence across broad taxonomic depths suggests that genes required to form a phylum are ancestral to that phylum. Therefore, rather than de novo gene genesis, we posit that evolutionary forces such as selection on existing genomic elements over large timescales may drive divergence and contribute to the emergence of phyla.
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影响因子:
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