Irisin: circulating levels in serum and its relation to gonadal axis.
Irisin: circulating levels in serum and its relation to gonadal axis.
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DOI：
10.1007/s12020-022-02981-5
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发表时间：
2022-03
期刊：
影响因子：
3.7
通讯作者：
Huang G
中科院分区：
文献类型：
--
作者：
Luo Y;Qiao X;Xu L;Huang G
Irisin是小鼠和人类运动诱导的肌细胞因子/脂肪因子，在白色脂肪组织的“布朗宁”中起重要作用，并且已经显示出作为一些代谢疾病（例如肥胖、胰岛素抵抗和炎症）的治疗的巨大潜力。据报道，循环中的鸢尾素水平与运动、肥胖、饮食、疾病和暴露于不同的药理学试剂有关。一些研究试图描述鸢尾素在PCOS和其他生殖疾病中的作用，但报道了相互矛盾的结果。我们之前的研究表明，鸢尾素可能在卵泡发生和生育能力方面发挥进一步的作用。本文就鸢尾素的生理功能及其在性腺轴中的作用作一综述。首先，我们描述了鸢尾素循环水平，并推测了鸢尾素分泌和调节的潜在机制。然后，我们将重点放在多囊卵巢综合征的鸢尾素水平，并探讨与BMI，胰岛素抵抗和高雄激素血症之间的关系。最后，我们提出了从动物干预研究和体外实验的结果，探讨鸢尾素和性腺轴的关系，表明其对生殖和生育的新的影响。
Irisin is an exercise-induced myokine/adipokine in mice and humans that plays an important role in ‘browning’ of white adipose tissue and has shown great potential as a treatment for some metabolic diseases, such as obesity, insulin resistance, and inflammation. The circulating irisin level is reported to be associated with exercise, obesity, diet, diseases, and exposure to different pharmacological agents. Several studies have attempted to characterize the role of irisin in PCOS and other reproductive diseases, but contradictory results have been reported. Our previous study showed that irisin may serve further functions in folliculogenesis and fertility. In this review, we present the current knowledge on the physiology of irisin and its role in gonadal axis. Firstly, we describe irisin circulating levels and speculate on the potential mechanisms involved in irisin secretion and regulation. Then, we focus on the irisin levels in PCOS, and explore the relationships between, BMI, insulin resistance, and hyperandrogenism. Finally, we present the results from animal interventional studies and in vitro experiments to investigate the relationship between irisin and gonadal axis, indicating its novel effects on reproduction and fertility.
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