Detection and potential utility of C-reactive protein in saliva of neonates.
Detection and potential utility of C-reactive protein in saliva of neonates.
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C反应蛋白在新生儿唾液中的检测和潜在效用。
DOI：
10.3389/fped.2014.00131
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发表时间：
2014
影响因子：
2.6
通讯作者：
Maron JL
中科院分区：
文献类型：
--
作者：
Iyengar A;Paulus JK;Gerlanc DJ;Maron JL
目的：检测新生儿唾液中的c反应蛋白（CRP）并评价其诊断价值。研究设计：收集40例新生儿的唾液和血清样本（n = 89）。采用酶联免疫吸附法测定唾液CRP水平；根据医院方案测定血清CRP。95%置信区间的相关系数和稳健线性回归测量了相关性，而受体-操作者特征曲线描述了唾液CRP在区分≥10和5 mg/L异常血清CRP阈值方面的准确性。对这些唾液切点计算相应的敏感性和特异性。结果：唾液CRP预测血清CRP水平≥10和5 mg/L的曲线下面积分别为0.81和0.76。唾液c反应蛋白对血清c反应蛋白≥5 mg/L的敏感性和特异性分别为0.54和0.95。唾液c反应蛋白鉴别≥10 mg/L血清c反应蛋白的敏感性和特异性分别为0.64和0.94。血清CRP与唾液CRP的相关性有统计学意义（r = 0.62, p < 0.001）。结论：新生儿唾液中可检测到c反应蛋白，可预测血清CRP阈值异常。唾液CRP分析是检测异常血清CRP水平的可行筛选工具。
Objective: We aimed to detect C-reactive protein (CRP) in neonatal saliva and evaluate its diagnostic utility. Study Design: Salivary and serum samples (n = 89) were collected from 40 neonates. Salivary CRP levels were determined using an enzyme-linked immunosorbent assay; serum CRP was measured per hospital protocol. Correlation coefficients with 95% confidence intervals and robust linear regression measured association while receiver–operator characteristic curves described the accuracy of salivary CRP in discriminating abnormal serum CRP thresholds of ≥10 and 5 mg/L. Corresponding sensitivities and specificities were calculated for these salivary cutpoints. Results: The area under the curve for salivary CRP in predicting serum CRP levels of ≥10 and 5 mg/L were 0.81 and 0.76, respectively. The corresponding sensitivity and specificity for raw salivary CRP to discriminate a serum CRP of ≥5 mg/L was 0.54 and 0.95, respectively. The corresponding sensitivity and specificity for raw salivary CRP to discriminate a serum CRP of ≥10 mg/L was 0.64 and 0.94, respectively. A statistically significant correlation was observed between serum and salivary CRP (r = 0.62, p < 0.001). Conclusion: C-reactive protein is detectable in neonatal saliva and can predict abnormal serum CRP thresholds. Salivary CRP analysis represents a feasible screening tool for detecting abnormal serum CRP levels.
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影响因子：
15.1
作者：
Out, Dorothee;Hall, Rosalie J.;Granger, Douglas A.;Page, Gayle G.;Woods, Stephanie J.
通讯作者：
Woods, Stephanie J.
影响因子：
--
作者：
Harrison, LM;Morris, JA;Telford, DR
通讯作者：
Telford, DR
影响因子：
7.6
作者：
Li, Y;Zhou, X;Wong, DTW
通讯作者：
Wong, DTW
影响因子：
3
作者：
Walsh, NP;Montague, JC;Rowlands, AV
通讯作者：
Rowlands, AV
影响因子：
4.3
作者：
KAAPA, P;KOISTINEN, E
通讯作者：
KOISTINEN, E