Help from peripheral macrophages in ALS?
Help from peripheral macrophages in ALS?
复制标题
ALS 中外周巨噬细胞的帮助?
DOI:
10.1038/s41593-020-00727-y
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发表时间:
2020
影响因子:
25
通讯作者:
Özdinler,PHande
中科院分区:
文献类型:
--
作者:
Özdinler,PHande
Chiot and colleagues investigated whether peripheral macrophages play a role in amyotrophic lateral sclerosis (ALS) pathology, finding that macrophages along peripheral motor neuron axons react to neurodegeneration. Modifying reactive oxygen species (ROS) signaling in peripheral macrophages, using bone marrow cell replacement, reduces both macrophage and microglia inflammatory response, delays pathology and increases survival in ALS mouse models.
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影响因子:
4.6
作者:
R. Mallya;D. Vergani;D. Tee;L. Bevis;F. C. D. Beer;Hedley Berry;E. Hamilton;B. Mace;M. B. Pepys
通讯作者:
M. B. Pepys
影响因子:
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作者:
KAPLAN, RA;CURD, JG;VAUGHAN, JH
通讯作者:
VAUGHAN, JH
影响因子:
15.9
作者:
U. Nydegger;R. Zubler;R. Gabay;G. Joliat;C. Karagevrekis;P. Lambert;P. Miescher
通讯作者:
P. Miescher
影响因子:
158.5
作者:
CHENOWETH, DE;COOPER, SW;KIRKLIN, JW
通讯作者:
KIRKLIN, JW
影响因子:
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作者:
S. Ruddy;K. Austen
通讯作者:
K. Austen