Effects of maternal or paternal bisphenol A exposure on offspring behavior.
Effects of maternal or paternal bisphenol A exposure on offspring behavior.
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DOI：
10.1016/j.yhbeh.2017.09.017
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发表时间：
2018-05
影响因子：
3.5
通讯作者：
Rissman EF
中科院分区：
文献类型：
--
作者：
Harris EP;Allardice HA;Schenk AK;Rissman EF
双酚A(BPA)是一种内分泌干扰性化学品，用于聚碳酸酯塑料和树脂的生产。孕期接触双酚A被认为是导致神经行为障碍的危险因素，如自闭症谱系障碍。为了解决发育过程中暴露于双酚A的行为影响，我们测试了怀孕期间每天暴露于低剂量双酚A的小鼠的后代。我们还询问了先入为主的父系暴露是否会影响后代的行为。交配前摄入双酚A 50天的雌性比对照组体重要轻，但对任何生殖指标都没有影响。与对照组相比，母亲而不是父母亲暴露于BPA的幼年后代在高架+迷宫的张开双臂上花费的时间更少，这表明焦虑样行为增加。然而，在社会认知任务中，父母暴露组和对照组都没有显著差异。我们还在两个新的任务中评估了母亲暴露于母亲的后代的行为：幼崽的超声波发声(USVs)和成年动物的操作反转学习。母体双酚A暴露增加了幼崽在母体分离期间发射USV的持续时间和中值频率。在反转学习任务中，女性的反应比男性更准确，获得的回报也更多。此外，在任务的习得阶段，对照雌鼠比双酚A雌鼠获得更多的奖励。这是第一批研究双酚A暴露是否会影响后代行为的研究之一，也是第一次报道孕期双酚A暴露对幼崽USV和成年操作者反应的影响的研究。
Bisphenol A (BPA) is an endocrine disrupting chemical used in the production of polycarbonate plastics and resins. Exposure to BPA during gestation has been proposed as a risk factor for the development of neurobehavioral disorders, such as autism spectrum disorder. To address the behavioral impact of developmental exposure to BPA, we tested offspring of mice exposed to a daily low dose of BPA during pregnancy. We also asked if preconception exposure of the sire affected behaviors in offspring. Sires that consumed BPA for 50 days prior to mating weighed less than controls, but no effects on any reproductive measures were noted. Juvenile offspring exposed to BPA maternally, but not paternally, spent less time in the open arms of the elevated plus maze than controls, indicating increased anxiety-like behavior. However, neither parental exposure group differed significantly from controls in the social recognition task. We also assessed the behaviors of maternally exposed offspring in two novel tasks: ultrasonic vocalizations (USVs) in pups and operant reversal learning in adults. Maternal BPA exposure increased the duration and median frequency of USVs emitted by pups during maternal separation. In the reversal learning task, females responded more accurately and earned more rewards than males. Additionally, control females received more rewards than BPA females during the acquisition phase of the task. These are among the first studies conducted to ask if BPA exposure via the sire affects offspring behavior and the first study to report effects of gestational BPA exposure on pup USVs and adult operant responding.
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影响因子：
10.4
作者：
Braun JM;Yolton K;Dietrich KN;Hornung R;Ye X;Calafat AM;Lanphear BP
通讯作者：
Lanphear BP
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影响因子：
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作者：
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通讯作者：
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影响因子：
3.5
作者：
Cox, Kimberly H.;Gatewood, Jessica D.;Howeth, Chelsea;Rissman, Emilie F.
通讯作者：
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