Biliary tract cancers in Olmsted County, Minnesota, 1976-2008.
Biliary tract cancers in Olmsted County, Minnesota, 1976-2008.
复制标题
DOI：
10.1038/ajg.2012.173
复制
发表时间：
2012-08
影响因子：
9.8
通讯作者：
Kim, W. Ray
中科院分区：
文献类型：
--
作者：
Yang, Ju Dong;Kim, Bohyun;Sanderson, Schuyler O.;St Sauver, Jennifer;Yawn, Barbara P.;Larson, Joseph J.;Therneau, Terry M.;Roberts, Lewis R.;Gores, Gregory J.;Kim, W. Ray
在过去的几十年里，美国的胆道癌流行病学发生了变化。本研究的目的是评估1976年至2008年间奥姆斯特德县胆道癌的发病率、病因、治疗和存活率。20岁以上的社区居民新诊断为胆道癌，使用罗切斯特流行病学项目进行鉴定。从病历中提取临床信息，包括肿瘤分期、治疗和生存状况。根据2000年美国人口普查，考虑到奥姆斯特县的整个人口都处于危险之中，并按年龄和性别进行调整，计算出发病率。评估了胆道癌患者生存的时间趋势。共有116名受试者符合研究标准。1976至2008年间，经年龄、性别调整的肝内胆管细胞癌(ICC)发病率从每10万人年0.3例增加到2.1例(p=0.02)，而胆囊癌从每10万人年4.0例下降到2.2例(p=0.04)(p<；0.01)。其余胆道癌的总体发病率没有变化。总体而言，59%的患者出现了3期或4期癌症，中位生存期为6.3个月。从1976年到2008年，胆道癌患者的生存期从中位生存期4.2个月提高到了7.7个月(p=0.05)。在奥姆斯特县，ICC和GB癌症的发病率分别上升和下降。在被诊断为胆道癌的社区居民中，预后仍然很差。
The epidemiology of biliary tract cancers has changed in the United States in the past several decades. The aim of this study is to evaluate biliary tract cancers with regard to the incidence rates, etiology, treatment, and survival in Olmsted County between 1976 and 2008. Community residents over 20 years of age with a newly diagnosed biliary tract cancers were identified using the Rochester Epidemiology Project. Clinical information, including tumor stage, treatment, and survival status was abstracted from the medical records. The incidence rate was calculated considering the entire population of Olmsted County to be at risk and adjusted by age and sex according to US Census 2000 population. Temporal trends of patient survival with biliary tract cancers were assessed. A total of 116 subjects met the study criteria. The age-sex-adjusted incidence rate of intrahepatic cholangiocarcinoma(ICC) increased from 0.3 to 2.1 (p=0.02) but one of gall bladder (GB) cancer decreased from 4.0 to 2.2 (p=0.04)per 100,000 person-years between 1976 and 2008 (p<0.01). Overall incidence rates of remaining biliary tract cancers have not changed. Overall 59% of patients presented with stage 3 or 4 cancers and a median survival was 6.3 months. Survival in patients with biliary tract cancer has minimally improved from median survival of 4.2 to 7.7 months between 1976 and 2008 (p=0.05). In Olmsted County, the incidence of ICC and GB cancer has increased and decreased, respectively. The prognosis remains poor in community residents diagnosed with biliary tract cancers.
登录
查看更多内容
影响因子：
29.4
作者：
Luna, Laura E. Moreno;Kipp, Benjamin;Gores, Gregory J.
通讯作者：
Gores, Gregory J.
影响因子：
8.4
作者：
Wood, R;Fraser, LA;Garden, OJ
通讯作者：
Garden, OJ
影响因子：
25.7
作者：
Shaib, YH;Davila, JA;El-Serag, HB
通讯作者：
El-Serag, HB
影响因子：
25.7
作者：
Khan, SA;Taylor-Robinson, SD;Thomas, HC
通讯作者：
Thomas, HC
影响因子：
5
作者：
St Sauver, Jennifer L.;Grossardt, Brandon R.;Rocca, Walter A.
通讯作者：
Rocca, Walter A.