Cytokine levels throughout the perinatal period.
Cytokine levels throughout the perinatal period.
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DOI：
10.1080/14767058.2021.1887121
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发表时间：
2022-12
期刊：
影响因子：
--
通讯作者：
Case AJ
中科院分区：
文献类型：
--
作者：
Moore TA;Case AJ
炎症过程失调与围产期并发症有关，但缺乏对围产期细胞因子水平的全面描述。我们报告了29种独特的细胞因子的前瞻性系列水平，这些细胞因子在妊娠期间的母体血液、出生时的脐带血和新生儿血液中测量。从中西部三级医疗中心招募孕妇（n = 140）。在5个时间点采集血液：12-20周、24-28周、妇女分娩时、出生时脐带、新生儿24-72小时。使用基于电化学发光的免疫测定法分析细胞因子水平。测量了29种细胞因子的水平。数据分为两组：有（n = 82）和无重大并发症（n = 53）（早产，先兆子痫，糖尿病）的妊娠。18种细胞因子显示随时间的显著变化（p <0.002）。大多数细胞因子在新生儿中最高。在任何时间点，并发症组之间的细胞因子水平均无差异。这是第一个已知的研究报告前瞻性的，连续的细胞因子水平在整个围产期的怀孕/无并发症。在有/无并发症的患者中，母体细胞因子水平没有差异;需要更大样本量的研究来验证我们目前的研究结果。结果还表明，细胞因子失调可能更局限于胎盘，使其难以测量和预测在怀孕期间使用母体全身血液标本。
Dysregulation of inflammatory processes is linked to perinatal complications yet a comprehensive description of cytokine levels throughout the perinatal period is lacking. We report prospective, serial levels of 29 unique cytokines measured in maternal blood during pregnancy, in the cord blood at birth, and in the neonatal blood. Pregnant women (n = 140) for recruited from a Midwest tertiary medical center. Blood was obtained at five timepoints: 12–20 weeks, 24–28 weeks, and at labor in the women, umbilical cord at birth, 24–72 h in the newborn. Cytokine levels were analyzed using an electrochemiluminescence-based immunoassay. Levels for 29 cytokines were measured. The data were separated into two groups: pregnancies with (n = 82) and without major complications (n = 53) (preterm birth, preeclampsia, diabetes mellitus). Eighteen cytokines showed significant changes over time (p < .002). The majority of the cytokines were highest in the newborn. No differences in cytokine levels between complication groups were noted at any timepoint. This is the first known study to report prospective, serial cytokine levels throughout the perinatal period for pregnancies with/without complications. No differences in maternal cytokine levels between those with/without complications were detected; studies with a larger sample size would be needed to validate our current findings. Results also suggest cytokine dysregulation may be more localized to the placenta making it difficult to measure and predict during pregnancy using maternal systemic blood specimens.
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影响因子：
3.8
作者：
Denney JM;Nelson EL;Wadhwa PD;Waters TP;Mathew L;Chung EK;Goldenberg RL;Culhane JF
通讯作者：
Culhane JF
DOI：
10.1016/s2215-0366(20)30006-7
发表时间：
2020-03
期刊：
The lancet. Psychiatry
影响因子：
--
作者：
Allswede DM;Yolken RH;Buka SL;Cannon TD
通讯作者：
Cannon TD
影响因子：
2
作者：
Ashford, Kristin B.;Chavan, Niraj;O'Brien, John
通讯作者：
O'Brien, John
影响因子：
2.5
作者：
Moore, Tiffany A.;Ahmad, Iman M.;Zimmerman, Matthew C.
通讯作者：
Zimmerman, Matthew C.
DOI：
10.1111/aji.12265
发表时间：
2014-09
期刊：
American journal of reproductive immunology (New York, N.Y. : 1989)
影响因子：
--
作者：
Ferguson KK;McElrath TF;Chen YH;Mukherjee B;Meeker JD
通讯作者：
Meeker JD