Modulatory mechanisms of cortisol effects on emotional learning and memory: novel perspectives.
Modulatory mechanisms of cortisol effects on emotional learning and memory: novel perspectives.
复制标题
DOI：
10.1016/j.psyneuen.2013.06.012
复制
发表时间：
2013-09
影响因子：
3.7
通讯作者：
Abercrombie, Heather C.
中科院分区：
文献类型：
--
作者：
van Ast, Vanessa A.;Cornelisse, Sandra;Marin, Marie-France;Ackermann, Sandra;Garfinkel, Sarah N.;Abercrombie, Heather C.
人们早就知道皮质醇会影响学习和记忆过程。尽管有大量研究致力于皮质醇对学习和记忆的影响，但其影响的强度甚至方向性往往各不相同。改变皮质醇对学习和记忆影响的许多因素是众所周知的。例如，皮质醇的影响可以通过情绪唤醒和正在研究的记忆阶段来调节。尽管在理解解释皮质醇影响变异性的因素方面取得了巨大进展，但皮质醇对记忆影响的其他调节剂的存在在当前的基础实验研究中尚未得到广泛认可。当前综述的目的是传播有关不太为人所知的皮质醇对学习和记忆影响的调节剂的知识。由于焦虑病因学的几种模型，例如创伤后应激障碍（PTSD），将压力和随之而来的皮质醇释放作为重要的脆弱因素，因此加强对皮质醇对记忆产生有益而不是有害影响的机制的理解非常重要。进一步阐明调节（或改变）皮质醇对记忆的影响的因素将有助于协调基础文献和临床文献中看似不一致的发现。本综述基于美国纽约第 42 届国际心理神经内分泌学会会议的一次研讨会，该研讨会重点介绍了其中一些调节剂及其基本机制。
It has long been known that cortisol affects learning and memory processes. Despite a wealth of research dedicated to cortisol effects on learning and memory, the strength or even directionality of the effects often vary. A number of the factors that alter cortisol’s effects on learning and memory are well-known. For instance, effects of cortisol can be modulated by emotional arousal and the memory phase under study. Despite great advances in understanding factors that explain variability in cortisol’s effects, additional modulators of cortisol effects on memory exist that are less widely acknowledged in current basic experimental research. The goal of the current review is to disseminate knowledge regarding less well-known modulators of cortisol effects on learning and memory. Since several models for the aetiology of anxiety, such as post-traumatic stress disorder (PTSD), incorporate stress and the concomitant release of cortisol as important vulnerability factors, enhanced understanding of mechanisms by which cortisol exerts beneficial as opposed to detrimental effects on memory is very important. Further elucidation of the factors that modulate (or alter) cortisol’s effects on memory will allow reconciliation of seemingly inconsistent findings in the basic and clinical literatures. The present review is based on a symposium as part of the 42nd International Society of Psychoneuroendocrinology Conference, New York, USA, that highlighted some of those modulators and their underlying mechanisms.
登录
查看更多内容
影响因子：
4.8
作者：
Abercrombie HC;Jahn AL;Davidson RJ;Kern S;Kirschbaum C;Halverson J
通讯作者：
Halverson J
影响因子：
25
作者：
Kindt, Merel;Soeter, Marieke;Vervliet, Bram
通讯作者：
Vervliet, Bram
影响因子：
25
作者：
Chun, MM;Phelps, EA
通讯作者：
Phelps, EA
影响因子：
17.7
作者：
Geracioti, TD;Baker, DG;Kasckow, JW
通讯作者：
Kasckow, JW
影响因子：
2.7
作者：
Bagot, Rosemary C.;van Hasselt, Felisa N.;Joels, Marian
通讯作者：
Joels, Marian