Male vitamin D status and male factor infertility.
Male vitamin D status and male factor infertility.
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DOI：
10.1016/j.fertnstert.2021.06.035
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发表时间：
2021-10
影响因子：
6.7
通讯作者：
Steiner AZ
中科院分区：
文献类型：
--
作者：
Banks N;Sun F;Krawetz SA;Coward RM;Masson P;Smith JF;Trussell JC;Santoro N;Zhang H;Steiner AZ
确定男性伴侣体内维生素D水平与轻度男性因素不育夫妇生育结果之间的关系。对美国9个生育中心的随机对照试验进行二次分析，精子浓度在5 M/mL至15 M/mL之间，活力≤40%，或正常形态≤4%的男性（N = 154）符合条件。女性伴侣处于排卵期，年龄≤40岁，输卵管通畅。男性提供精液和血液作为精液分析和25-羟基维生素D （250HD）水平的基线。他们被随机分配接受维生素制剂，包括每天2000国际单位的维生素D或安慰剂长达6个月。夫妇在前3个月尝试自然受孕，在第4至6个月使用克罗米芬与女性伴侣进行宫内人工授精。初级：基线时的精子浓度、活力、形态和DNA片段；继发性：累积妊娠、流产和活产率维生素D缺乏的男性与25OHD水平≥20 ng/mL的男性相比，精液参数和精子DNA断裂无统计学差异。临床妊娠率和活产率也相似。男性25OHD水平< 20 ng/mL与较高的流产率相关[校正OR 9.0 (95% CI 1.3 ~ 61.3), p = 0.024]男性伴侣维生素D缺乏对精液参数或治疗结果没有显著影响。有必要进一步研究以更好地描述男性维生素D缺乏夫妇的流产率。在一项随机对照试验的二次分析中，男性伴侣维生素D缺乏对精液参数或生育治疗结果没有显著影响。
To determine the association between vitamin D levels in the male partner and fertility outcomes in couples with mild male factor infertility. Secondary analysis of a randomized, controlled trial Nine fertility centers in the United States Males (N = 154) with sperm concentration between 5 M/mL and 15 M/mL, motility ≤ 40%, or normal morphology ≤ 4% were eligible. Female partners were ovulatory, ≤ 40 years old, and had documented tubal patency. Men provided semen and blood at baseline for semen analysis and 25-hydroxyvitamin D (250HD) levels. They were randomly assigned to receive a vitamin formulation including Vitamin D 2000 IU daily or placebo for up to 6 months. Couples attempted to conceive naturally during the first 3 months and with clomiphene citrate with intrauterine insemination of the female partner in months 4 through 6. Primary: sperm concentration, motility, morphology, and DNA fragmentation at baseline; Secondary: cumulative pregnancy, miscarriage, and live birth rates Semen parameters and sperm DNA fragmentation were not statistically significantly different in males with vitamin D deficiency compared to males with 25OHD levels ≥ 20 ng/mL. Clinical pregnancy and live birth rates were also similar. Male 25OHD level < 20 ng/mL was associated with a higher pregnancy loss rate [adjusted OR 9.0 (95% CI 1.3 to 61.3), p = 0.024] Vitamin D deficiency in the male partner did not significantly impact semen parameters or treatment outcomes. Further study is warranted to better characterize the rate of miscarriage in couples with male vitamin D deficiency. Vitamin D deficiency in the male partner did not significantly impact semen parameters or fertility treatment outcomes in a secondary analysis of a randomized controlled trial.
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影响因子：
2.9
作者：
Hammoud, Ahmad O.;Meikle, A. Wayne;Carrell, Douglas T.
通讯作者：
Carrell, Douglas T.
DOI：
10.1016/0022-4731(90)90274-v
发表时间：
1990-02-01
影响因子：
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作者：
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影响因子：
4.2
作者：
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通讯作者：
DELUCA, HF
影响因子：
2.9
作者：
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通讯作者：
Yao, Bing