Female rats self-administer heroin by vapor inhalation.
Female rats self-administer heroin by vapor inhalation.
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DOI：
10.1016/j.pbb.2020.173061
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Taffe MA
中科院分区：
文献类型：
--
作者：
Gutierrez A;Nguyen JD;Creehan KM;Taffe MA
过去二十年来，美国阿片类药物的医疗和非医疗使用显着增加，导致与阿片类药物相关的过量用药和死亡人数创历史新高。 2002 年左右，处方阿片类药物的非医疗使用最初出现增加，随后海洛因使用增加，最近芬太尼使用增加。吸入是阿片类药物的常见给药途径，有记录的历史可以追溯到地中海古代，一直到现代电子烟设备的使用。不幸的是，使用吸入作为给药途径的临床前研究仍然相对较少。本研究旨在确定电子烟蒸气吸入大鼠海洛因的功效。非偶然接触海洛因或美沙酮蒸气对雄性和雌性大鼠产生抗伤害作用。训练雌性老鼠自我注射海洛因蒸气；当蒸气载体中的海洛因浓度降低并且用阿片受体拮抗剂纳洛酮预处理时，最喜欢的一半分布获得了更多的蒸气强化剂。海洛因蒸气自我给药的抗伤害作用与静脉自我给药产生的抗伤害作用大小相同。最后，在最后一次使用海洛因蒸气后 24-48 小时，焦虑样行为增加，这与静脉自我给药后观察到的戒断症状一致。总之，这些研究表明，使用电子烟技术通过蒸气吸入对大鼠产生海洛因的奖励和抗伤害作用。重要的是，可以采用这种途径的自我给药模型来确定吸入海洛因或其他阿片类药物对健康的影响。
Over the last two decades the United States has experienced a significant increase in the medical and non-medical use of opioid drugs, resulting in record numbers of opioid-related overdoses and deaths. There was an initial increase in non-medical use of prescription opioids around 2002, followed later by increased heroin use and then most recently fentanyl. Inhalation is a common route of administration for opioids, with a documented history spanning back to Mediterranean antiquity and up through modern use with e-cigarette devices. Unfortunately, preclinical studies using inhalation as the route of administration remain relatively few. This study was conducted to determine the efficacy of e-cigarette vapor inhalation of heroin in rats. Non-contingent exposure to heroin or methadone vapor produced anti-nociceptive efficacy in male and female rats. Female rats were trained to self-administer heroin vapor; the most-preferring half of the distribution obtained more vapor reinforcers when the concentration of heroin was reduced in the vapor vehicle and when pre-treated with the opioid receptor antagonist naloxone. The anti-nociceptive effect of heroin self-administered by vapor was identical in magnitude to that produced by intravenous self-administration. Finally, anxiety-like behavior increased 24–48 hours after last heroin vapor access, consistent with withdrawal signs observed after intravenous self-administration. In sum, these studies show that rewarding and anti-nociceptive effects of heroin are produced in rats by vapor inhalation using e-cigarette technology. Importantly, self-administration models by this route can be deployed to determine health effects of inhaled heroin or other opioids.
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影响因子：
3.6
作者：
Javadi-Paydar, Mehrak;Creehan, Kevin M.;Taffe, Michael A.
通讯作者：
Taffe, Michael A.
影响因子：
2.7
作者：
Bertoglio, LJ;Carobrez, AP
通讯作者：
Carobrez, AP
影响因子：
3.6
作者：
Braun, Amanda A.;Skelton, Matthew R.;Vorhees, Charles V.;Williams, Michael T.
通讯作者：
Williams, Michael T.
影响因子：
3.6
作者：
HANDLEY, SL;MITHANI, S
通讯作者：
MITHANI, S
影响因子：
3.6
作者：
Cicero, TJ;Aylward, SC;Meyer, ER
通讯作者：
Meyer, ER