Aflatoxin Exposure Among Mothers and Their Infants from the Western Highlands of Guatemala.-猫眼课题宝

DOI：

10.1007/s10995-021-03151-1

发表时间：

2021-08

期刊：

Maternal and child health journal

影响因子：

2.3

通讯作者：

中科院分区：

医学4区

文献类型：

作者：

Jolly PE;Mazariegos M;Contreras H;Balas N;Junkins A;Aina IO;Minott S;Wang M;Phillips TD

来源链接：

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404172/

我们检测了添加辅食前后母亲的母乳和婴儿的尿液中的黄曲霉毒素M1 (AFM1)，以及AFM1与母亲和婴儿饮食之间的关系。本研究于2014年6 - 10月对0-6个月和7-12个月的母婴进行前瞻性队列研究。收集了社会人口、饮食、出生和健康数据。在基线（时间点1）和此后每月（2个时间点）采集每位母亲的母乳样本和每位婴儿的尿液样本；在基线和时间点3采集样本进行AFM1检测。近5%的母乳和15.7%的尿液样本检测出afm1阳性。母乳中AFM1的中位数为0.020 ng/mL，尿中肌酐为0.077 ng/mg。在时间点3，每组6名母亲中有5名母乳中afm1阳性的婴儿尿液中也有afm1阳性。母亲每周食用熟玉米/玉米面团≥3天（OR 2.96, 95% CI = 1.19-7.34）和母亲每周食用玉米粉蒸肉≥3天（OR 0.28, 95% CI = 0.10-0.73）与婴儿尿液AFM1显著相关。这是危地马拉首次记录哺乳母亲的母乳和婴儿出生后第一年尿液中黄曲霉毒素暴露情况的研究。这可能对理解危地马拉5岁以下儿童发育迟缓率高的多重原因具有重要意义。

We examined breast milk of mothers and urine of infants before and after introduction of supplementary foods for aflatoxin M1 (AFM1) and the association between AFM1 with maternal and infant diet. A prospective cohort study was conducted among mothers and infants ages 0–6 months and 7–12 months from June-October 2014. Sociodemographic, dietary, birth, and health data were collected. A breast milk sample was collected from each mother and a urine sample from each infant at baseline (time point 1) and monthly for 2 time points thereafter; samples collected at baseline and time point 3 were tested for AFM1. Almost 5% of breast milk and 15.7% of urine samples tested AFM1-positive. The median AFM1 in breast milk was 0.020 ng/mL and in urine 0.077 ng/mg creatinine. At time point 3, infants of 5 of the 6 mothers in each group who were AFM1-positive in breast milk were also AFM1-positive in urine. Mothers’ consumption of cooked maize/maize dough ≥ 3 days per week (OR 2.96, 95% CI = 1.19–7.34) and mothers’ consumption of tamales made from maize ≥ 3 days per week (OR 0.28, 95% CI = 0.10–0.73) were significantly associated with AFM1 in infant urine. This is the first study in Guatemala documenting aflatoxin exposure in both breast milk of lactating mothers and infantś urine during the first year of life. This may have important implications in understanding the multicausality of the high rates of stunting among children < 5 years old in Guatemala.