Enhanced vertical rectus contractility by magnetic resonance imaging in superior oblique palsy.
Enhanced vertical rectus contractility by magnetic resonance imaging in superior oblique palsy.
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DOI：
10.1001/archophthalmol.2011.152
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发表时间：
2011-07
影响因子：
--
通讯作者：
Demer, Joseph L.
中科院分区：
文献类型：
--
作者：
Clark, Robert A.;Demer, Joseph L.
鉴于 SO 麻痹的垂直偏差大大超过仅通过 SO 垂直作用丧失所解释的偏差，目的是使用磁共振成像寻找上斜肌 (SO) 麻痹的眼外肌体积、横截面积和收缩力的继发性变化的证据。使用 8 厘米视场和 2 毫米切片厚度，在 12 名慢性单侧 SO 麻痹患者和 36 名年龄匹配的健康志愿者中获得了目标控制中心凝视、上行和下行的高分辨率准冠状轨道磁共振图像。数字图像分析用于量化眼外直肌和 SO 横截面积和体积。将测量值与对照组的中央凝视测量值进行比较，以检测肥厚或萎缩，并在垂直凝视变化期间，检测过度收缩性。在中央凝视中，麻痹性 SO 显着萎缩 (P<.001)，对侧上直肌 (SR) 显着肥厚 (P=.02)。在从上直肌到下直肌的垂直收缩范围内，对侧 SR (P=.04) 和下直肌 (P=.001) 的最大横截面积均表现出显着的超常收缩变化。同侧 SR 和下直肌的收缩变化表现出相似但不显着的趋势 (.08<P<.12)。对侧 SR 的中央凝视肥大可能是继发于慢性过度神经支配以补偿该眼的相对斜视。超正常的对侧 SR 和下直肌收缩力表明，垂直直肌眼外肌异常神经支配的动态模式可能导致 SO 麻痹中常见的大斜视。
To seek evidence for causative secondary changes in extraocular muscle volume, cross-sectional area, and contractility in superior oblique (SO) palsy using magnetic resonance imaging, given that vertical deviations in SO palsy greatly exceed those explained by loss of SO vertical action alone. High-resolution, quasi-coronal orbital magnetic resonance images in target-controlled central gaze, supraduction, and infraduction were obtained in 12 patients with chronic unilateral SO palsy and 36 age-matched healthy volunteers using an 8-cm field of view and 2-mm slice thickness. Digital image analysis was used to quantify rectus extraocular muscle and SO cross-sectional areas and volumes. Measurements were compared with those of controls in central gaze to detect hypertrophy or atrophy and during vertical gaze changes to detect excess contractility. In central gaze, the paretic SO was significantly atrophic (P<.001) and the contralesional superior rectus (SR) was significantly hypertrophic (P=.02). Across the range of vertical duction from supraduction to infraduction, both the contralesional SR (P=.04) and inferior rectus (P=.001) exhibited significantly supernormal contractile changes in maximum cross-sectional area. Contractile changes in the ipsilesional SR and inferior rectus exhibited a similar but insignificant trend (.08<P<.12). Central gaze hypertrophy of the contralesional SR may be secondary to chronic excess innervation to compensate for relative hypotropia of this eye. Supernormal contralesional SR and inferior rectus contractility suggests that dynamic patterns of abnormal innervation to vertical rectus extraocular muscles may contribute to large hypertropias often observed in SO palsy.
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影响因子：
--
作者：
Kushner, BJ
通讯作者：
Kushner, BJ
影响因子：
1.8
作者：
ROBINSON, DA
通讯作者：
ROBINSON, DA
影响因子：
4.2
作者：
BOEDER, P
通讯作者：
BOEDER, P
影响因子：
13.7
作者：
Jiang L;Demer JL
通讯作者：
Demer JL
DOI：
10.1016/0010-4809(84)90012-0
发表时间：
1984-01-01
期刊：
COMPUTERS AND BIOMEDICAL RESEARCH
影响因子：
--
作者：
MILLER, JM;ROBINSON, DA
通讯作者：
ROBINSON, DA