Chronic scream sound exposure alters memory and monoamine levels in female rat brain
Chronic scream sound exposure alters memory and monoamine levels in female rat brain
复制标题
慢性尖叫声暴露会改变雌性大鼠大脑的记忆和单胺水平
DOI：
10.1016/j.physbeh.2014.06.012
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发表时间：
2014-10
期刊：
影响因子：
--
通讯作者：
Chen Huang
中科院分区：
文献类型：
--
作者：
Lumin Wang;Yang Yang;Tusheng Song;Chen Huang
长期的尖叫声会改变雄性大鼠的认知能力和它们的大脑单胺水平，这些压力引起的改变是两性二态的。为了确定声应激对雌性大鼠的影响，我们检测了它们的血清皮质酮水平、肾上腺、脾和胸腺重量、认知表现以及大脑中单胺类神经递质及其代谢物的水平。采用Morris水迷宫对成年雌性Sprague-Dawley大鼠的空间学习和记忆能力进行了测试。应激降低血清皮质酮水平，以及脾和肾上腺重量。它还会损害空间记忆，但不会影响学习能力。在前额皮质（PFC）、纹状体、下丘脑和海马中测量单胺和代谢物。PFC内多巴胺（DA）水平降低，同型香草酸/DA比值升高。纹状体内DA降低，5-羟基吲哚乙酸（5-HIAA）升高。只有下丘脑的5-HIAA水平升高。在海马体中，应激不影响单胺和代谢物的水平。结果表明，尖叫声应激对雌性大鼠的大部分生理参数、记忆、单胺类神经递质及其代谢物的水平都有影响。
Chronic scream sound alters the cognitive performance of male rats and their brain monoamine levels, these stress-induced alterations are sexually dimorphic. To determine the effects of sound stress on female rats, we examined their serum corticosterone levels and their adrenal, splenic, and thymic weights, their cognitive performance and the levels of monoamine neurotransmitters and their metabolites in the brain. Adult female Sprague–Dawley rats, with and without exposure to scream sound (4 h/day for 21 day) were tested for spatial learning and memory using a Morris water maze. Stress decreased serum corticosterone levels, as well as splenic and adrenal weight. It also impaired spatial memory but did not affect the learning ability. Monoamines and metabolites were measured in the prefrontal cortex (PFC), striatum, hypothalamus, and hippocampus. The dopamine (DA) levels in the PFC decreased but the homovanillic acid/DA ratio increased. The decreased DA and the increased 5-hydroxyindoleacetic acid (5-HIAA) levels were observed in the striatum. Only the 5-HIAA level increased in the hypothalamus. In the hippocampus, stress did not affect the levels of monoamines and metabolites. The results suggest that scream sound stress influences most physiologic parameters, memory, and the levels of monoamine neurotransmitter and their metabolites in female rats.
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影响因子：
2.5
作者：
LIVEZEY, GT;MILLER, JM;VOGEL, WH
通讯作者：
VOGEL, WH
影响因子：
2.9
作者：
Beck, KD;Luine, VN
通讯作者：
Luine, VN
影响因子：
3.7
作者：
KANT, GJ;LENOX, RH;MEYERHOFF, JL
通讯作者：
MEYERHOFF, JL
DOI：
10.1007/s004210050479
发表时间：
1998-12-01
期刊：
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY
影响因子：
--
作者：
Kappel, M;Poulsen, TD;Pedersen, BK
通讯作者：
Pedersen, BK
影响因子：
3.6
作者：
Rai, D;Bhatia, G;Singh, HK
通讯作者：
Singh, HK