Developmental appearance and disappearance of cortical events and oscillations in infant rats.
Developmental appearance and disappearance of cortical events and oscillations in infant rats.
复制标题
DOI：
10.1016/j.brainres.2010.01.088
复制
发表时间：
2010-04-09
期刊：
影响因子：
2.9
通讯作者：
Blumberg, Mark S.
中科院分区：
文献类型：
--
作者：
Seelke, Adele M. H.;Blumberg, Mark S.
直到最近，幼鼠有组织的和状态依赖的新皮层活动被认为是从出生后第11天（P）δ波的出现开始的。随着出生后不久就可检测到的几种形式的皮层活动的发现，包括纺锤波爆发（SB）和慢活动瞬变（SAT），这种观点正在改变。在这里，我们提供了进一步的证据，令人惊讶的丰富的皮质活动模式在早期发展和文件，在P5-P13大鼠，出现，消失，和短暂的表达三个皮质事件和振荡。使用16通道层状硅电极和Ag-AgCl电极记录未麻醉、头部固定受试者的额叶、顶叶和枕叶皮质的EEG活动。除了SAT，我们还发现了两种新的活动形式：皮层锐电位（CSP）和伽马爆发（GB）。在这些区域未观察到SB。CSP被定义为持续时间为250 ms的离散双相事件，表现出倒U型发展轨迹，在P9时患病率达到峰值。相反，GBs（定义为40 Hz活动的短暂爆发）的患病率和持续时间从P5到P13稳步增加。SAT的患病率在这里测试的年龄段稳步下降。此外，CSP和GB更可能发生在睡眠期间而不是清醒期间。由于SAT、CSP和GB表现出不同的发育轨迹和发生率，并且可以彼此独立地发生，因此它们似乎是不同的神经元活动模式。我们假设这些不同的神经生理活动模式反映了发育中的新皮层的瞬时局部结构和连通性。
Until recently, organized and state-dependent neocortical activity in infant rats was thought to commence with the emergence of delta waves at postnatal day (P)11. This view is changing with the discovery of several forms of cortical activity that are detectible soon after birth, including spindle bursts (SBs) and slow activity transients (SATs). Here we provide further evidence of surprisingly rich cortical activity patterns during early development and document, in P5-P13 rats, the appearance, disappearance, and transient expression of three cortical events and oscillations. EEG activity in frontal, parietal, and occipital cortices was recorded in unanesthetized, head-fixed subjects using 16-channel laminar silicon electrodes and Ag-AgCl electrodes. In addition to SATs, we identified two novel forms of activity: cortical sharp potentials (CSPs) and gamma bursts (GBs). SBs were not observed in these areas. CSPs, defined as discrete, biphasic events with a duration of 250 ms, exhibited an inverted-U developmental trajectory with peak prevalence at P9. In contrast, GBs, defined as brief bursts of 40-Hz activity, increased steadily in prevalence and duration from P5 through P13. The prevalence of SATs decreased steadily across the ages tested here. Furthermore, both CSPs and GBs were more likely to occur during sleep than during wakefulness. Because SATs, CSPs, and GBs exhibit different developmental trajectories and rates of occurrence, and can occur independently of each other, they appear to be distinct patterns of neuronal activity. We hypothesize that these diverse patterns of neurophysiological activity reflect the instantaneous local structure and connectivity of the developing neocortex.
登录
查看更多内容
影响因子：
5.3
作者：
Hanganu, Ileana L.;Staiger, Jochen F.;Khazipov, Rustem
通讯作者：
Khazipov, Rustem
影响因子：
2.5
作者：
Minlebaev, Marat;Ben-Ari, Yehezkel;Khazipov, Rustem
通讯作者：
Khazipov, Rustem
影响因子：
3.4
作者：
Seelke, AMH;Karlsson, KAE;Blumberg, MS
通讯作者：
Blumberg, MS
影响因子：
1.9
作者：
Karlsson, KAE;Blumberg, MS
通讯作者：
Blumberg, MS
影响因子：
2.5
作者：
Karlsson, KAE;Blumberg, MS
通讯作者：
Blumberg, MS