Postnatal Vitamin D Intake Modulates Hippocampal Learning and Memory in Adult Mice.
Postnatal Vitamin D Intake Modulates Hippocampal Learning and Memory in Adult Mice.
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产后维生素 D 摄入可调节成年小鼠的海马学习和记忆
DOI：
10.3389/fnins.2018.00141
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发表时间：
2018
影响因子：
4.3
通讯作者：
Gao Z
中科院分区：
文献类型：
--
作者：
Liang Q;Cai C;Duan D;Hu X;Hua W;Jiang P;Zhang L;Xu J;Gao Z
维生素 D (VD) 是一种神经活性类固醇，对大脑发育、功能和体内平衡至关重要。它的缺乏与许多大脑疾病有关。因此，VD 及其变体通常被患有/不患有已知 VD 缺乏症的广泛群体所服用。相比之下，维生素D过量的有害影响却鲜有研究。同样，发育阶段特异性 VD 缺乏和过量的研究也很少。在目前的研究中，我们发现产后补充 VD 可以暂时增强年轻人的运动功能，但对老年人则不然。出生后 VD 摄入异常不会影响焦虑和抑郁行为，但不利于空间学习和海马依赖性记忆。在分子水平上，我们未能观察到所检查的神经发育和活动相关基因有明显且持续的变化。然而，大多数基因的发育表达动态被破坏，这表明神经发育动态的改变以及因此异常的成人可塑性可能是功能缺陷的基础。我们的工作强调了 VD 稳态在神经发育和成人大脑功能中的本质。需要进一步的研究来确定 VD 摄入状态可能对大脑发育、体内平衡和疾病产生的短期和长期影响。
Vitamin D (VD) is a neuroactive steroid crucial for brain development, function and homeostasis. Its deficiency is associated with numerous brain conditions. As such, VD and its variants are routinely taken by a broad of groups with/without known VD deficiency. In contrast, the harmful effects of VD overdose have been poorly studied. Similarly, the developmental stage-specific VD deficiency and overdose have been rarely explored. In the present work, we showed that postnatal VD supplementation enhanced the motor function transiently in the young adult, but not in the older one. Postnatal VD intake abnormality did not impact the anxiety and depressive behavior but was detrimental to spatial learning and hippocampus-dependent memory. At the molecular level we failed to observe an obvious and constant change with the neural development and activity-related genes examined. However, disrupted developmental expression dynamics were observed for most of the genes, suggesting that the altered neural development dynamics and therefore aberrant adult plasticity might underlie the functional deficits. Our work highlights the essence of VD homeostasis in neural development and adult brain function. Further studies are needed to determine the short- and long-term effects VD intake status may have on brain development, homeostasis, and diseases.
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影响因子：
2.7
作者：
Burne, Thomas H. J.;O'Loan, Jonathon;Eyles, Darryl W.
通讯作者：
Eyles, Darryl W.
影响因子：
1.6
作者：
Burne, Thomas H. J.;Alexander, Suzanne;McGrath, John J.
通讯作者：
McGrath, John J.
影响因子：
3.7
作者：
Dean AJ;Bellgrove MA;Hall T;Phan WM;Eyles DW;Kvaskoff D;McGrath JJ
通讯作者：
McGrath JJ
影响因子：
5
作者：
Brouwer-Brolsma EM;Dhonukshe-Rutten RA;van Wijngaarden JP;van der Zwaluw NL;Sohl E;In't Veld PH;van Dijk SC;Swart KM;Enneman AW;Ham AC;van Schoor NM;van der Velde N;Uitterlinden AG;Lips P;Feskens EJ;de Groot LC
通讯作者：
de Groot LC
影响因子：
3.3
作者：
Eyles, D;Brown, J;Feron, F
通讯作者：
Feron, F