Small Fiber Polyneuropathy May Be a Nexus Between Autonomic Nervous System Dysregulation and Pain in Interstitial Cystitis/Bladder Pain Syndrome.
Small Fiber Polyneuropathy May Be a Nexus Between Autonomic Nervous System Dysregulation and Pain in Interstitial Cystitis/Bladder Pain Syndrome.
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DOI：
10.3389/fpain.2021.810809
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Walker SJ
中科院分区：
文献类型：
--
作者：
Wolff DT;Walker SJ
间质性膀胱炎/膀胱疼痛综合征 (IC/BPS) 是一种高度异质性的慢性衰弱性疾病，影响着美国数百万女性和男性。虽然 IC/BPS 主要定义为泌尿系统症状和感觉来自膀胱的疼痛，但 IC/BPS 患者经常同时出现病症和症状，其中许多影响与自主神经系统功能相关的多种身体系统。对自主系统的影响似乎源于泌尿道交感神经支配的增加，以及全身交感神经张力的增加和副交感神经张力的降低。与这些发现同时存在的是汗腺周围交感神经支配被破坏的证据，这可能与小纤维多发性神经病有关。目前尚不清楚自主神经功能的广泛改变在多大程度上也与携带自主神经支配的小纤维的破坏/改变相关。这种潜在的联系是一个重要的研究点，可以更好地了解间质性膀胱炎/膀胱疼痛综合征的未阐明的病理生理学、众多并发症状和综合征，并确定新的靶向治疗策略。
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a highly heterogeneous chronic and debilitating condition which effects millions of women and men in the United States. While primarily defined by urinary symptoms and pain perceived to be emanating from the bladder, IC/BPS patients frequently have co-occurring conditions and symptoms, many of which affect diverse body systems related to autonomic nervous system function. The impact on the autonomic system appears to stem from increased sympathetic innervation of the urinary tract, along with increased systemic sympathetic tone and decreased parasympathetic tone. Concurrent with these findings is evidence for destruction of peripheral sympathetic innervation to the sweat glands which may relate to small fiber polyneuropathy. It is unknown to what degree the wider alterations in autonomic function are also related to destruction/alterations in the small fibers carrying autonomic innervation. This potential nexus is an important point of investigation to better understand the unclarified pathophysiology of interstitial cystitis/bladder pain syndrome, the numerous co-occurring symptoms and syndromes, and for the identification of novel targeted therapeutic strategies.
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DOI：
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发表时间：
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