Cohort Profile Update: The Lothian Birth Cohorts of 1921 and 1936.

Cohort Profile Update: The Lothian Birth Cohorts of 1921 and 1936.
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DOI:
10.1093/ije/dyy022
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发表时间:
2018-08-01
影响因子:
7.7
通讯作者:
Deary IJ
Deary IJ
中科院分区:
医学1区
文献类型:
--
作者:
Taylor AM;Pattie A;Deary IJ

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1921年(LBC1921)和1936年(LBC1936)的洛锡安出生队列分别被设计为1932年苏格兰心理调查(SMS1932)和1947年苏格兰心理调查(SMS1947)的后续研究。1 1932年6月1日,SMS1932在苏格兰的所有学校同时进行,并使用了普通智力的Moray House测试(第12号;MHT)。几乎所有1921年出生的在校儿童都接受了测试。2几乎所有1936年出生并在1947年6月4日入学的儿童都接受了相同的MHT,以参加SMS1947(N?70805)。3正如2012年发表的队列概况所述,40年后,这两项调查的参与者--大多居住在爱丁堡及其周围地区(洛锡安人)--被邀请参加洛锡安出生队列研究。在1999至2001年间,550名SMS1932被招募到LBC1921研究的第一波,平均年龄为79岁。在2004至2007年间,SMS1947的1091名成员被招募到LBC1936研究的第一波,平均年龄为70岁。在最初的随访中,两组患者都重新进行了MHT检查。此外,还收集了大量其他认知、心理社会、生活方式、医学、生物标记物、遗传、脑成像等数据。有LBC19215和LBC1936,6的基线协议文章,以及LBC1936的单独的基线脑成像协议文章。7.
The original Lothian Birth Cohorts of 1921 (LBC1921) and 1936 (LBC1936) were designed as follow-up studies to the Scottish Mental Surveys of 1932 (SMS1932) and 1947 (SMS1947), respectively. 1 The SMS1932 took place simultaneously across schools in Scotland on 1 June 1932, and used the Moray House Test (No. 12; MHT) of general intelligence. Almost every child attending school and born in 1921 (N ¼ 87 498) was tested. 2 The same MHT was administered to almost every child born in 1936 and attending school on 4 June 4 1947 for the SMS1947 (N ¼ 70 805). 3 As described in the Cohorts Profile published in 2012, 4 decades later, participants of both Surveys, mostly living in Edinburgh and the surrounding area (the Lothians) in older age, were invited to participate in the Lothian Birth Cohort (LBC) studies. Between 1999 and 2001, 550 of the SMS1932 were recruited to Wave 1 of the LBC1921 study, at a mean age of 79 years. Between 2004 and 2007, 1091 members of SMS1947 were recruited to Wave 1 of the LBC1936 study, at a mean age of 70 years. Both cohorts re-sat the MHT at initial follow-up. In addition, a large amount of other cognitive, psychosocial, lifestyle, medical, biomarker, genetic, brain imaging and other data were collected. There are baseline protocol articles for LBC1921 5 and LBC1936, 6 and a separate baseline brain imaging protocol article for LBC1936. 7
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