Combining spatial and temporal information to explore resting-state networks changes in abstinent heroin-dependent individuals
Combining spatial and temporal information to explore resting-state networks changes in abstinent heroin-dependent individuals
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结合空间和时间信息探索戒断海洛因依赖个体的静息态网络变化
DOI：
10.1016/j.neulet.2010.03.033
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发表时间：
2010-05
影响因子：
2.5
通讯作者：
Wang, Yarong
中科院分区：
文献类型：
--
作者：
Yuan, Kai;Li, Qiang;Yang, Weichuan;Tian, Jie;Qin, Wei;Dong, Minghao;Liu, Jixin;Liu, Peng;Zhang, Yi;Sun, Jinbo;Wang, Wei;Wang, Yarong
以往的海洛因功能磁共振成像研究大多集中在海洛因依赖个体的异常脑功能上。然而，很少有fMRI研究关注海洛因依赖个体的静息状态异常，并评估静息状态功能连接变化与海洛因使用时间的关系。本研究采用离散余弦变换（DCT）研究海洛因依赖个体和健康被试静息状态下BOLD低频振荡的空间分布；同时利用静息状态功能连通性分析对两组DCT分析得到的重叠脑区时间特征进行分析。本研究的主要发现是海洛因依赖个体的默认模式网络（DMN）和吻侧前扣带皮层（rACC）网络与健康受试者相比发生了改变。更重要的是，这些变化与海洛因使用时间呈负相关。海洛因依赖个体的静息状态功能异常为海洛因依赖个体的功能组织异常提供了证据，如决策和抑制控制功能障碍。
Majority of previous heroin fMRI studies focused on abnormal brain function in heroin-dependent individuals. However, few fMRI studies focused on the resting-state abnormalities in heroin-dependent individuals and assessed the relationship between the resting-state functional connectivity changes and duration of heroin use. In the present study, discrete cosine transform (DCT) was employed to explore spatial distribution of low frequency BOLD oscillations in heroin-dependent individuals and healthy subjects during resting-state; meanwhile resting-state functional connectivity analysis was used to investigate the temporal signatures of overlapping brain regions obtained in DCT analysis among these two groups. Main finding of the present study is that the default mode network (DMN) and rostral anterior cingulate cortex (rACC) network of heroin-dependent individuals were changed compared with healthy subjects. More importantly, these changes negatively correlated with duration of heroin use. These resting-state functional abnormalites in heroin-dependent individuals provided evidence for abnormal functional organization in heroin-dependent individuals, such as functional impairments in decision-making and inhibitory control.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
年轻海洛因依赖者的灰质密度与海洛因使用时间呈负相关
影响因子：
2.5
作者：
Liu, YJ;Lee, TMC;Weng, XC;Yuan, Y;Yuan, F;Zou, ZL;Zhu, ZD;Shi, JF
通讯作者：
Shi, JF
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V
影响因子：
5.7
作者：
Fransson, Peter;Marrelec, Guillaume
通讯作者：
Marrelec, Guillaume
影响因子：
2.5
作者：
Fu, Li-ping;Bi, Guo-hua;Yang, Zheng
通讯作者：
Yang, Zheng