Multisystem resiliency moderates the major depression-telomere length association: findings from the Heart and Soul Study.
Multisystem resiliency moderates the major depression-telomere length association: findings from the Heart and Soul Study.
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DOI：
10.1016/j.bbi.2013.05.008
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发表时间：
2013-10
期刊：
影响因子：
--
通讯作者：
Cohen BE
中科院分区：
文献类型：
--
作者：
Puterman E;Epel ES;Lin J;Blackburn EH;Gross JJ;Whooley MA;Cohen BE
重度抑郁症 (MDD) 与白细胞端粒长度 (LTL) 缩短有关。然而，尚不清楚社会心理和行为保护因素是否会调节这种关联。在当前的研究中，我们研究了多系统弹性（由健康的情绪调节、强大的社会联系和健康行为（睡眠和运动）定义）是否可以预测 LTL 并减轻先前证明的抑郁症诊断与 LTL 之间的关联。在 Heart and Soul 研究中，使用定量 PCR 检测对 954 名患有稳定心血管疾病的患者进行了 LTL 测量。在完全调整的模型中，高多系统弹性可预测更长的 LTL（b = 80.00，SE = 27.17，p = .003），而每个单独的因素则不然。多系统弹性显着调节 MDD-LTL 关联 (p = .02)。具体而言，MDD 与 LTL 显着相关，低于多系统弹性平均值 1 SD（b = -142.86，SE = 56.46，p = .01），但高于平均值 1 SD 则不显着相关（b = 49.07，SE = 74.51，p = .51）。这项研究表明，MDD 与生物学结果的关联应该在心理社会行为背景下进行检查，因为这种背景决定了直接关系的性质。进一步的研究应该探索认知、神经和其他生理途径，多系统弹性可以通过这些途径带来生物学益处。
Major depressive disorder (MDD) has been associated with reduced leukocyte telomere length (LTL). It is not known, however, whether psychosocial and behavioral protective factors moderate this association. In the current study, we examine whether multisystem resiliency – defined by healthy emotion regulation, strong social connections, and health behaviors (sleep and exercise) – predicts LTL and mitigates previously demonstrated associations between depression diagnosis and LTL. LTL was measured, using a quantitative PCR assay, in 954 patients with stable cardiovascular disease in the Heart and Soul Study. In a fully adjusted model, high multisystem resiliency predicted longer LTL (b = 80.00, SE = 27.17, p = .003), whereas each individual factor did not. Multisystem resiliency significantly moderated the MDD-LTL association (p = .02). Specifically, MDD was significantly related to LTL at 1 SD below the mean of multisystem resiliency (b = −142.86, SE = 56.46, p = .01), but not at 1 SD above the mean (b = 49.07, SE = 74.51, p = .51). This study suggests that MDD associations with biological outcomes should be examined within a psychosocial–behavioral context, because this context shapes the nature of the direct relationship. Further research should explore the cognitive, neural, and other physiological pathways through which multisystem resiliency may confer biological benefit.
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