An investigation into the association between DNA damage and dietary fatty acid in men with prostate cancer.
An investigation into the association between DNA damage and dietary fatty acid in men with prostate cancer.
复制标题
DOI：
10.3390/nu7010405
复制
发表时间：
2015-01-08
期刊：
影响因子：
5.9
通讯作者：
Ferguson LR
中科院分区：
文献类型：
--
作者：
Bishop KS;Erdrich S;Karunasinghe N;Han DY;Zhu S;Jesuthasan A;Ferguson LR
前列腺癌在新西兰和全世界都是一个日益严重的问题，因为人们采用西式饮食模式。特别是，膳食脂肪被认为与氧化应激有关，而氧化应激又可能与癌症风险和发展有关。此外，DNA损伤与多种癌症的风险相关，被认为是评估食物对癌症影响的理想生物标志物。在这项研究中，20名前列腺癌患者坚持了三个月的改良地中海式饮食。饮食记录，血液脂肪酸水平，前列腺特异性抗原，C反应蛋白和DNA损伤进行了评估前和干预后。DNA损伤与饮食依从性（p = 0.013）、全血单不饱和脂肪酸（p = 0.009）和油酸（p = 0.020）呈负相关。DNA损伤与乳制品（p = 0.043），红肉（p = 0.007）和全血ω-6多不饱和脂肪酸（p = 0.015）的摄入量呈正相关。在饮食干预过程中，膳食脂肪的来源和类型都发生了显着变化。DNA损伤水平与各种膳食脂肪来源和膳食脂肪类型相关。
Prostate cancer is a growing problem in New Zealand and worldwide, as populations adopt a Western style dietary pattern. In particular, dietary fat is believed to be associated with oxidative stress, which in turn may be associated with cancer risk and development. In addition, DNA damage is associated with the risk of various cancers, and is regarded as an ideal biomarker for the assessment of the influence of foods on cancer. In the study presented here, 20 men with prostate cancer adhered to a modified Mediterranean style diet for three months. Dietary records, blood fatty acid levels, prostate specific antigen, C-reactive protein and DNA damage were assessed pre- and post-intervention. DNA damage was inversely correlated with dietary adherence (p = 0.013) and whole blood monounsaturated fatty acids (p = 0.009) and oleic acid (p = 0.020). DNA damage was positively correlated with the intake of dairy products (p = 0.043), red meat (p = 0.007) and whole blood omega-6 polyunsaturated fatty acids (p = 0.015). Both the source and type of dietary fat changed significantly over the course of the dietary intervention. Levels of DNA damage were correlated with various dietary fat sources and types of dietary fat.
登录
查看更多内容
影响因子：
4.6
作者：
Kanwal, Rajnee;Pandey, Mitali;Bhaskaran, Natarajan;MacLennan, Gregory T.;Fu, Pingfu;Ponsky, Lee E.;Gupta, Sanjay
通讯作者：
Gupta, Sanjay
影响因子：
7.1
作者：
Harris, William S.
通讯作者：
Harris, William S.
影响因子：
6.4
作者：
Ganmaa, D;Li, XM;Sato, A
通讯作者：
Sato, A
影响因子：
1.9
作者：
Bailey-Hall, Eileen;Nelson, Edward B.;Ryan, Alan S.
通讯作者：
Ryan, Alan S.
影响因子：
2.6
作者：
Dhillon, VS;Thomas, P;Fenech, M
通讯作者：
Fenech, M