Postnatal feeding with high-fat diet induces obesity and precocious puberty in C57BL/6J mouse pups: a novel model of obesity and puberty
Postnatal feeding with high-fat diet induces obesity and precocious puberty in C57BL/6J mouse pups: a novel model of obesity and puberty
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产后高脂饮食喂养导致 C57BL/6J 小鼠幼崽肥胖和性早熟：一种新型的肥胖和青春期模型
DOI：
10.1007/s11684-017-0530-y
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发表时间：
2017-06
影响因子：
8.1
通讯作者：
Fu Junfen
中科院分区：
文献类型：
--
作者：
Ullah Rahim;Su Yan;Shen Yi;Li Chunlu;Xu Xiaoqin;Zhang Jianwei;Huang Ke;Rauf Naveed;He Yang;Cheng Jingjing;Qin Huaping;Zhou Yu-Dong;Fu Junfen
儿童肥胖和肥胖相关的代谢并发症是由高脂肪的产后饮食引起的。然而，缺乏合适的动物模型仍然是肥胖研究的一个相当大的挑战。在本研究中，我们分别在哺乳期和断奶后给公鼠饲喂高脂肪饲粮。我们还建立了一种新的hfd诱导的C57BL/6J小鼠幼鼠模型。结果表明，高脂饲料可引起幼鼠脂肪沉积和肥胖。此外，高脂饲料对雄性幼犬体重的增加作用强于雌性幼犬。饲喂hfd的雌性幼鼠肥胖，性早熟，下丘脑kisspeptin表达增加。然而，父母肥胖和性早熟对hfd诱导的幼鼠出生后体重增加和性早熟没有协同作用。有趣的是，一些BW正常的hfd喂养的幼崽也表现出性早熟。这一发现表明，饮食成分而不是体重触发青春期的发生。我们的模型显示肥胖与性早熟具有良好的建构效度。此外，我们的模型还可以用于探索饮食诱导的产后儿童肥胖与青春期之间的相互作用。
Childhood obesity and obesity-related metabolic complications are induced by a high-fat postnatal diet. The lack of a suitable animal model, however, remains a considerable challenge in obesity studies. In the current study, we provided high-fat diet (HFD) to dams during lactation and to pups after weaning. We also developed a novel model of C57BL/6J mouse pups with HFD-induced postnatal obesity. Results showed that feeding with HFD induces fat deposition and obesity in pups. Furthermore, HFD more potently increased the body weight (BW) of male than female pups. HFD-fed female pups were obese, underwent precocious puberty, and showed increased kisspeptin expression in the hypothalamus. However, parental obesity and precocious puberty exerted no synergistic effects on the HFD-induced postnatal weight gain and puberty onset of the pups. Interestingly, some HFD-fed litters with normal BW also exhibited precocious puberty. This finding suggested that diet composition but not BW triggers puberty onset. Our model suggests good construction validity of obesity and precocious puberty. Furthermore, our model can also be used to explore the mutual interactions between diet–induced postnatal childhood obesity and puberty.
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影响因子：
3.7
作者：
Barron AM;Rosario ER;Elteriefi R;Pike CJ
通讯作者：
Pike CJ
影响因子：
6.9
作者：
Fu, Jun-Fen;Liang, Jian-Feng;Rose, Susan Rogers
通讯作者：
Rose, Susan Rogers
饮食能量密度与美国成年人的肥胖症和其他慢性疾病的生物标志物有关。
影响因子：
5
作者：
Vernarelli JA;Mitchell DC;Rolls BJ;Hartman TJ
通讯作者：
Hartman TJ
影响因子：
3.2
作者：
Barber, T. M.;McCarthy, M. I.;Franks, S.
通讯作者：
Franks, S.
DOI：
10.1073/pnas.1834399100
发表时间：
2003-09-16
影响因子：
11.1
作者：
de Roux, N;Genin, E;Milgrom, E
通讯作者：
Milgrom, E