Long-lasting sensitization of reward-directed behavior by amphetamine.
Long-lasting sensitization of reward-directed behavior by amphetamine.
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DOI：
10.1016/j.bbr.2009.01.034
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发表时间：
2009-07-19
影响因子：
2.7
通讯作者：
Setlow, Barry
中科院分区：
文献类型：
--
作者：
Mendez, Ian A.;Williams, Matthew T.;Bhavsar, Atasi;Lu, Annie P.;Bizon, Jennifer L.;Setlow, Barry
暴露于滥用的精神兴奋剂药物（如安非他明）可导致奖励导向行为的长期“敏化”，例如受试者表现出由奖励和奖励预测线索导向的行为增强（即“激励敏化”）。这些实验的目的是确定慢性安非他明暴露导致的这种致敏作用对食欲和消费性食物动机行为的影响程度。成年雄性Long-Evans大鼠连续5天每天腹腔注射d-苯丙胺（2.0 mg/kg）或生理盐水溶剂。这种安非他明暴露方案对药物的急性运动刺激作用产生持久的致敏作用。药物暴露后一个月，在各种反应时间表下测试大鼠对食物奖励的工具反应（压杆）。在药物暴露后两个月，在辨别性巴甫洛夫情境强化进食任务中测试大鼠的食物消耗，该任务涉及一个有食物的情境和另一个没有食物的情境的配对。安非他明暴露的大鼠表现出显着更大的工具响应食物奖励比盐水对照，特别是在高响应比的条件下。在强化进食任务中，在食物饱足的条件下进行的测试显示，在食物配对的情况下，安非他明暴露的大鼠比盐水对照组吃得更多。这些实验表明，安非他明暴露可以导致持久的增加食欲和消费方面的自然奖励导向的行为。这种持久的激励敏感化可以部分解释药物成瘾复发的倾向，以及报告的非药物奖励相关行为的增强。
Exposure to psychostimulant drugs of abuse such as amphetamine can result in long-lasting “sensitization” of reward-directed behavior, such that subjects display enhancements in behavior directed by and toward rewards and reward-predictive cues (i.e. – “incentive sensitization”). The purpose of these experiments was to determine the degree to which such sensitization resulting from chronic amphetamine exposure influences both appetitive and consummatory food-motivated behavior. Adult male Long-Evans rats received daily i.p. injections of d-amphetamine (2.0 mg/kg) or saline vehicle for five consecutive days. This amphetamine exposure regimen produced lasting sensitization to the acute locomotor stimulant effect of the drug. One month after drug exposure rats were tested for instrumental responding (lever pressing) for food reward under various response schedules. Two months after drug exposure, rats were tested for food consumption in a discriminative Pavlovian context-potentiated eating task, involving pairings of one context with food and another context with no food. Amphetamine-exposed rats showed significantly greater instrumental responding for food reward than saline controls, particularly under conditions of high response ratios. In the potentiated eating task, testing under conditions of food satiation revealed that amphetamine-exposed rats ate significantly more than saline controls in the food-paired context. These experiments demonstrate that amphetamine exposure can cause enduring increases in both appetitive and consummatory aspects of natural reward-directed behavior. Such long-lasting incentive sensitization could account in part for the propensity for relapse in drug addiction, as well as for reported enhancements in non-drug reward-related behavior.
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影响因子：
5.3
作者：
Olausson, Peter;Jentsch, J. David;Taylor, Jane R.
通讯作者：
Taylor, Jane R.
影响因子：
2.6
作者：
MITTENBERG, W;MOTTA, S
通讯作者：
MOTTA, S
影响因子：
5.6
作者：
Nordquist, R. E.;Voorn, P.;Vanderschuren, L. J. M. J.
通讯作者：
Vanderschuren, L. J. M. J.
影响因子：
--
作者：
Everitt, BJ;Dickinson, A;Robbins, TW
通讯作者：
Robbins, TW
影响因子：
3.4
作者：
LETT, BT
通讯作者：
LETT, BT