Association between cytomegalovirus infection, reduced gray matter volume, and resting-state functional hypoconnectivity in major depressive disorder: a replication and extension.
Association between cytomegalovirus infection, reduced gray matter volume, and resting-state functional hypoconnectivity in major depressive disorder: a replication and extension.
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DOI：
10.1038/s41398-021-01558-6
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发表时间：
2021-09-07
影响因子：
6.8
通讯作者：
Savitz J
中科院分区：
文献类型：
--
作者：
Zheng H;Ford BN;Kuplicki R;Burrows K;Hunt PW;Bodurka J;Kent Teague T;Irwin MR;Yolken RH;Paulus MP;Savitz J
人巨细胞病毒（HCMV）是一种嗜神经性疱疹病毒，已知可引起免疫力受损患者的神经病理学。以前，我们报道了两个独立的样本中，与HCMV血清阴性（HCMV-）的匹配参与者相比，HCMV血清阳性（HCMV+）的参与者的几个脑区的灰质体积（GMV）减少。除了GMV结果的独立复制外，本研究旨在检查HCMV+是否与静息状态功能连接（rsfMRI-FC）的差异相关。在使用治疗加权逆概率（IPTW）对11个临床/人口统计学变量进行平衡后，从99名重度抑郁症（MDD）参与者中获得GMV和rsfMRI-FC，这些参与者被分为42名HCMV+和57名HCMV−个体。相对于HCMV−组，HCMV+组在9个皮质区域中显示出GMV显著降低。在先前的研究中也观察到HCMV+组的右侧眶额皮质（标准化β系数（SBC）= −0.32，[95%CI，−0.62至−0.02]）和左侧眶部（SBC = −0.34，[95%CI，−0.63至−0.05]）的体积减少。无论采用何种分组方法或分析方法，相对于HCMV−组，HCMV+组在感觉运动网络的枢纽（双侧中央后回）和显著性网络的枢纽（双侧海马）之间显示出低连通性，效应量范围为SBC = −0.57至−0.99。这些研究结果支持这一假设，一个积极的HCMV血清状态与改变连接的区域，是重要的压力和情感处理，并进一步支持一个可能的病因作用，HCMV抑郁症。
Human cytomegalovirus (HCMV) is a neurotropic herpes virus known to cause neuropathology in patients with impaired immunity. Previously, we reported a reduction in the gray matter volume (GMV) of several brain regions in two independent samples of participants who were seropositive for HCMV (HCMV+) compared to matched participants who were seronegative for HCMV (HCMV−). In addition to an independent replication of the GMV findings, this study aimed to examine whether HCMV+ was associated with differences in resting-state functional connectivity (rsfMRI-FC). After balancing on 11 clinical/demographic variables using inverse probability of treatment weighting (IPTW), GMV and rsfMRI-FC were obtained from 99 participants with major depressive disorder (MDD) who were classified into 42 HCMV+ and 57 HCMV− individuals. Relative to the HCMV− group, the HCMV+ group showed a significant reduction of GMV in nine cortical regions. Volume reduction in the right lateral orbitofrontal cortex (standardized beta coefficient (SBC) = −0.32, [95%CI, −0.62 to −0.02]) and the left pars orbitalis (SBC = −0.34, [95%CI, −0.63 to −0.05]) in the HCMV+ group was also observed in the previous study. Regardless of the parcellation method or analytical approach, relative to the HCMV− group, the HCMV+ group showed hypoconnectivity between the hubs of the sensorimotor network (bilateral postcentral gyrus) and the hubs of the salience network (bilateral insula) with effect sizes ranging from SBC = −0.57 to −0.99. These findings support the hypothesis that a positive HCMV serostatus is associated with altered connectivity of regions that are important for stress and affective processing and further supports a possible etiological role of HCMV in depression.
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DOI：
10.1038/nrn3950
发表时间：
2015-07
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Barrett LF;Simmons WK
通讯作者：
Simmons WK
影响因子：
11.2
作者：
DAVIS, LE;JOHNSON, RT
通讯作者：
JOHNSON, RT
影响因子：
15.1
作者：
Burgdorf, Kristoffer Solvsten;Trabjerg, Betina B.;Ullum, Henrik
通讯作者：
Ullum, Henrik
影响因子：
4.2
作者：
Carbone, Ilaria;Lazzarotto, Tiziana;Licastro, Federico
通讯作者：
Licastro, Federico
DOI：
10.15288/jsa.1998.59.427
发表时间：
1998-07-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Brown, SA;Myers, MG;Vik, PW
通讯作者：
Vik, PW